A -- RESEARCH & DEVELOPMENT -- THE SUBJECT TECHNOLOGY IS A SET OF FOUR COMPOUNDS THAT APPEARS TO BE USEFUL IN ALLEVIATING THE TOXIC EFFECTS OF ACETALDEHYDE (ACH). ACH, THE FIRST METABOLIC PRODUCT OF INGESTED ETHANOL (ETHYL ALCOHOL), IS KNOWN TO EXHIBIT LIVER TOXICITY AND IS SUSPECTED IN THE ETIOLOGY

Notice Date

November 13, 2001

Contracting Office

National Technology Transfer Center, Wheeling Jesuit University, 316 Washington Ave., Wheeling, WV 26003-6295

ZIP Code

26003-6295

Solicitation Number

#99-071

Response Due

December 20, 2001

Point of Contact

Mr. William Chard at 1-800-678-6882 or (304) 243-2039.

E-Mail Address

click here to contact the contracting officer via (wchard@nttc.edu)

Description

N-Terminal Dipeptides of D (-) Penicillamine as Sequestration Agents for Aldehydes -- -- -- -- -- The Department of Veterans Affairs (VA), through the National Technology Transfer Center (NTTC), is seeking a commercialization partner to further develop this technology through a Cooperative Research and Development Agreement (CRADA). -- -- -- -- -The subject technology is a set of four compounds that appears to be useful in alleviating the toxic effects of acetaldehyde (AcH). AcH, the first metabolic product of ingested ethanol (ethyl alcohol), is known to exhibit liver toxicity and is suspected in the etiology of alcoholic liver disease. There is reason to believe that these compounds may work as sequestration agents for aldehydes generally, including formaldehyde (the first metabolic product of methanol) and glutaraldehyde, as well as AcH. On this basis, it is hypothesized that any one or more of these compounds are candidates for use as an antidote against the toxic effects of AcH, formaldehyde and glutaraldehyde, and thus may be effective both in treatment of chronic alcoholism and in cases of acute alcohol or aldehyde poisoning. A secondary effect may be the reduction of the offensive body odor produced by unsaturated aldehydes.

Web Link

Click here to find out additional information regarding (www.nttc.edu)

Record

Loren Data Corp. 20011115/ASOL005.HTM (W-317 SN5128W9)