A -- RESEARCH & DEVELOPMENT -- THE VA HAS DISCOVERED A NOVEL INSULIN GENE AND A METHOD OF GENE TRANSCRIPTION TO REGULATE INSULIN PRODUCTION BY COUPLING INSULIN SECRETION TO AMBIENT GLUCOSE LEVELS FOR GENE THERAPY TREATMENT OF TYPE1 INSULIN-DEPENDENT DIABETES MELLITUS.

Notice Date

November 13, 2001

Contracting Office

National Technology Transfer Center, Wheeling Jesuit University, 316 Washington Ave., Wheeling, WV 26003-6295

ZIP Code

26003-6295

Solicitation Number

#99-003

Response Due

December 20, 2001

Point of Contact

Mr. William Chard at 1-800-678-6882 or (304) 243-2039

E-Mail Address

Click here to contact the contracting officer via (wchard@nttc.edu)

Description

Glucose Sensitive Regulator of Insulin Transcription -- -- -- -- The Department of Veterans Affairs (VA), through the National Technology Transfer Center (NTTC), is seeking a commercialization partner to further develop this technology through a Cooperative Research and Development Agreement (CRADA). -- -- -- The VA has discovered a novel insulin gene and a method of gene transcription to regulate insulin production by coupling insulin secretion to ambient glucose levels for gene therapy treatment of Type1 insulin-dependent diabetes mellitus. The VA research has demonstrated the utility of the coupled glucose- and insulin-sensitive promoter to appropriately regulate the production and secretion of transgenic insulin from hepatocytes both in vitro and in vivo, by utilizing transcription to control transgene expression. The research confirms that the promoter possesses the capacity to regulate transgenic insulin production from liver cells in response to metabolic signals regarding the need for insulin.

Web Link

Click here for more information regarding this technology (www.nttc.edu)

Record

Loren Data Corp. 20011115/ASOL004.HTM (W-317 SN5128X9)