A -- IN-VIVO EFFICACY IN DISEASE RELATED MODELS

Notice Date

October 15, 2001

Contracting Office

Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Research Contracts Br., 6120 Executive Blvd. EPS Room 604, Rockville, MD, 20852

ZIP Code

20852

Solicitation Number

N01CM27026

Response Due

November 30, 2001

Point of Contact

MaryAnne Golling, Contracting Officer, Phone (301) 435-3819, Fax (301) 402-6699, Email mg345x@nih.gov -- Nancy Coleman, Contracting Officer, Phone (301) 435-3820, Fax (301) 402-6699, Email nc31y@nih.gov

Description

The Developmental Therapeutics program, DCTD, NCI through the In-Vivo Efficacy in Disease-Related Models Master Agreement pool, is interested in a study to contrast the behavior of 17-AAG (NSC 330507) against that of 17-DMAG (NSC 707545) using a panel of characterized tumor cell lines/xenografts with respect to growth inhibition and modulation of hsp90, c-erbB2, her3, raf-1, Ah, CDK4, cyclin D, akt, P akt and PI 3 kinase as well as the induction of apoptosis. The purpose of Request for Proposals (RFP) N01-CM-27026 is to A) systematically evaluate the expression of the molecular targets hsp90, erbB2, her3, raf, Ah, CDK4, cyclin D, akt, Pakt, and PI 3 kinase activity with associated apoptosis using a specific set of melanoma xenografts/cell lines, and B) utilize the best erbB2 positive (+) and negative (-) lines regardless of histology of origin for SRB and clonogenic assays with up to six corresponding in vivo models chosen for investigation of the same parameters. Those interested in obtaining a copy of this RFP should send their e-mail address to MaryAnne Golling at mg354x@nih.gov and a copy of the RFP will be forwarded electronically. AN AWARD WILL ONLY BE MADE TO A MASTER AGREEMENT HOLDER IN THE IN-VIVO EFFICACY MASTER AGREEMENT POOL.. The North American Industry Classification System (NAICS) code is 541710. Proposals will only be considered from OFFERORS IN THE MASTER AGREEMENT HOLDER POOL. Those who are not currently in the In-Vivo Efficacy in Disease-Related Models Master Agreement pool and who wish to be considered for inclusion should consult the Research Contracts Branch website at http://amb.nci.nih.gov under Current Requests for Proposals and refer to RFP/N01-CM-97017-54. Potential offerors will be responsible for downloading their own copy of the solicitation and amendments. The duration of the existing Master Agreement pool is April 28, 1999 through April 27, 2004. The due date for proposals is October 30 of each year for those interest in being included in the projected annual review. Questions should be directed via e-mail or facsimile to MaryAnne Golling, Contracting Officer, fax (301) 402-6699. No collect call will be accepted.=20

Web Link

Visit this URL for the latest information about this (http://www.eps.gov/spg/HHS/NIH/RCB/N01CM27026/listing.html)

Record

Loren Data Corp. 20011017/ASOL001.HTM (D-288 SN5106J4)