A -- NATIONAL CENTER FOR TOXICOGENOMICS PROTEOMICS RESOURCE!!

Notice Date

August 22, 2001

Contracting Office

National Institutes of Environmental Health Sciences, Research Contracts Branch, DERT, P.O. Box 12874, Building 4401, Research Commons, 79 T.W. Alexander Drive, Research Triangle Park, NC 27709

ZIP Code

27709

Solicitation Number

NIH-ES-01-14

Response Due

December 11, 2001

Point of Contact

Jo Ann Lewis,Contracting Officer, (919)541-7894 or email:lewisj@niehs.nih.gov

Description

The National Institute of Environmental Health Sciences (NIEHS) is soliciting proposals for the purpose of (1) using proteomics technology for identifying critical proteins affected by chemical treatments in experimental biological systems (Task 1), and (2) providing a protein expression profile database based on two dimensional gel electrophoresis (2D gel) images and mass spectral (MS) identification and containing data analysis and data mining tools (Task 2). Specifically, the Contractor shall provide sample preparation for 2D gel electrophoresis; separation of samples by 2D gels, image analysis and protein excision and protein digestion; protein identification by mass spectrometry; develop and implement an integrated Laboratory Information Management System (LIMS), furnish a relational prototype database to store and preserve the integrity of protein expression data generated; and host, maintain, update and secure the database system. Offeror may propose either or both Tasks. One or more awards are anticipated with an award date of June 3, 2002. The period of performance is expected to be five (5) years. For estimating purposes the Government estimates the level-of-effort as follows: Proteomic Analysis Capabilities (Task 1): 13,624 direct labor hours per year as Senior Professional -- 2,704 direct labor hours (i.e., Principal Investigator, mass spectrometry leader, bioinformatics leader); Other Professionals -- 10,400 direct labor hours (i.e., computer technical, laboratory technician); Administrative Support -- 520 direct labor hours. The Prototype Toxicoproteomics Expression Database System (Task 2): 7,800 direct labor hours per year as Senior Professional -- 2,080 direct labor hours (i.e., Principal Investigator/Bioinformatics leader); Other Professionals -- 5,200 direct labor hours (i.e., computer technician); and Administrative Support -- 1,040 direct labor hours. The anticipated release date of the RFP is September 10, 2001 with proposals due December 11, 2001. Interested firms should telefax a request for RFP NIH-ES-01-14 to the attention of Ms. Melissa Gentry, Procurement Technician at (919) 541-2712 or send an e-mail request to gentry1@niehs.nih.gov. The electronic version of the CBD synopsis is available on the Internet at http://www.niehs.nih.gov/dert/rcb/rfp.htm. An electronic copy of the RFP will be posted to this site on or about September 10, 2001. This requirement is unrestricted. NAICS is 541710.

Record

Loren Data Corp. 20010824/ASOL007.HTM (W-234 SN50V770)