66 -- MASSARRAY SYSTEM

Notice Date

August 13, 2001

Contracting Office

Department of Health and Human Services, National Institutes of Health, Office of Administration, 6011 Executive Blvd, Rm 538, Rockville, MD, 20892-7663

ZIP Code

20892-7663

Solicitation Number

263-01-P-(DD)0086

Response Due

August 30, 2001

Point of Contact

Larry Manning, Contract Specialist, Phone 301-402-3067, Fax 301-435-8514, Email manninl@od.nih.gov -- Larry Manning, Contract Specialist, Phone 301-402-3067, Fax 301-435-8514, Email manninl@od.nih.gov

Description

The MassARRAY system shall include the following: a. Biflex array mass spectrometer for separation, detection and characterization of the analyte molecules from a miniaturized array; configured with a 10-chip MALDI target or better. b. 4 -- channel, v1.4, dispenser for nanoliter sample transfer from microliter plate to SpectroCHIP or better.=09 c. Automated 96 -- channel Multipipettor supporting both 96 and 384 format microplates or better. d. Data management and interpretation tools including Workstation (server hardware) and Oracle -- based allele calling software or equivalent. e. Installation within six weeks of receipt of a order for the Mass ARRAY System or equivalent . f. Access to scientific and engineering support staff as needed for extended lengths of time to provide training and guidance in terms of assay development and general operation of the System. g. 2 X 384 SpectroCHIPs 10-pack or equivalent. 2 The System shall be highly accurate to a level of 99% or better, to avoid the cost of repeat typing, or to increase the already large size of patient populations to be studied 3. The system shall use the method of combining a multiple base primer extension and a mass spectrometry method that measures allele-specific products on the basis of mass.=20 4. The system shall have a minimum throughput of 50,000 genotypes per day. 5. The system shall have available a database of validated Single Nucleotide Polymorphisms (SNP) assays that have been mapped to specific regions of the human genome. System shall have at least 20,000 SNPs genome-wide in the database at the present time, and have at least 100 validated SNPs in each of the following genomic regions: 1. D1S389 -- D1S204 2. D4S2410 -- D4S1576 3. D12S364 -- D12S1650 The National Institutes of Health intends to acquire the above stated Commercially available MassARRAY System on a Sole-Source basis. It is the Government's belief that this requirement may only be met by Sequenom Inc. This is not a formal solicitation, however, concerns that respond to this notice must furnish concise responses directed specifically to the requirements mentioned above. Sources demonstrating the capability to accomplish the above shall supply pertinent information in sufficient detail to demonstrate their ability to perform within 15 days of this notice. A determination by the Government not to compete this proposed contract based upon the responses to the notice is solely within the discretion of the Government. Information furnished shall include enough material to perform a proper evaluation. Respondents will not be notified of the evaluation results. Address responses to the attention of Mr. Larry Manning at the National Institutes of Health, 6011 Executive Blvd., Room 537F, Rockville MD. 20892. FAX responses are acceptable at 301-402-8514. The proposed contract action is for supplies and services for which the Government intends to solicit and negotiate under the authority of FAR 6.302.1 NOTE: NUMBERED Note 22.

Web Link

Visit this URL for the latest information about this (http://www.eps.gov/spg/HHS/NIH/OoA/263-01-P-(DD)0086/listing.html)

Record

Loren Data Corp. 20010815/66SOL011.HTM (D-225 SN50U7N9)