A -- STUDIES OF CHEMICAL DISPOSITION IN MAMMALS!!

Notice Date

June 18, 2001

Contracting Office

National Institutes of Environmental Health Sciences, Research Contracts Branch, DERT, P.O. Box 12874, Building 4401, Research Commons, 79 T.W. Alexander Drive, Research Triangle Park, NC 27709

ZIP Code

27709

Solicitation Number

NIH-ES-01-09

Response Due

August 14, 2001

Point of Contact

Contact Howard Hill, Contract Specialist, (919)541-4971

Description

The purpose of this project is to obtain detailed chemical disposition data from 3 to 6 studies per year of selected environmental contaminants or model compounds per year. The purpose of this contract is to procure detailed chemical disposition data from a number of selected environmental contaminants or model compounds per year. Most of these studies will be conducted in Fischer 344 rats and/or B6C3F1 mice. There are infrequent occasions where other strains of rats (e.g. Sprague-Dawley) or mice (e.g. Swiss-Webster) will be required to meet the needs of the NTP. Rarely, other laboratory rodent species such as hamsters will be required. (Note: For costing purposes, offerors should assume that all studies will be conducted in Fischer 344 rats and/or B6C3F1 mice.) Most studies will address the disposition of organic chemicals; however, studies of inorganic chemicals may also be requested. Individual studies may vary in complexity from preliminary investigations of chemical absorption to detailed studies of all phases of chemical disposition, toxicokinetics, and metabolism. The immediate goal of these studies is to provide data to be used in determination of dose, route of administration, and interpretation of NTP bioassay studies. The long-range goal is the accumulation of data that will permit a better assessment of structure-activity relationships for chemical absorption, metabolism, and disposition in laboratory animals and to better interpret the significance of these data to humans. This project will cover a five year period with two awards. The government estimates that the project will require approximately 2.0 professional person-years and 3.0 technical person years per contract year. All requests must reference RFP No.NIH-ES-01-09 and must be directed to the office listed above. All responsible sources may submit a proposal which shall be considered by the Agency.

Record

Loren Data Corp. 20010620/ASOL003.HTM (W-169 SN50P248)