A -- MILLENNUIM VACCINE INITIATIVE -- NOVEL VACCINES FOR TUBERCULOSIS AND MALARIA

Notice Date

May 3, 2001

Contracting Office

Department of Health and Human Services, National Institutes of Health, National Institutes of Allergy and Infectious Diseases, Contract Management Branch, 6700-B Rockledge Drive, MSC 7612, Bethesda, MD, 20892-7612

ZIP Code

20892-7612

Solicitation Number

NIH-NIAID-DMID-02-15

Response Due

September 17, 2001

Point of Contact

Glynis Fisher, Contract Specialist, Phone 301-496-3699, Fax 301-402-0972, Email gfisher@niaid.nih.gov -- Jacqueline Holden, Senior Contracting Officer, Phone 301-496-7119, Fax 301-402-0972, Email

E-Mail Address

Glynis Fisher (gfisher@niaid.nih.gov)

Description

RFP Available: NIH-NIAID-DMID-02-15 _Millennuim Vaccine Initiative _ Novel Vaccines for Tuberculosis and Malaria._ The Parasitology and International Programs Branch and the Respiratory Diseases Branch, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) have a requirement to promote development of vaccines against malaria and tuberculosis. To augment the vaccine product pipeline, we are seeking opportunities to advance novel approaches and concepts for vaccines against these two diseases towards product stages via a focused, development-based approach. The goal of these efforts is the development of novel, safe and immunogenic vaccine prototypes that can be taken into clinical development. The purpose of this Request for Proposals is to solicit proposals for application of state-of-the-art vaccine technologies available within the private sector to accelerate the development of effective vaccines for malaria and tuberculosis. Specifically, this Request for Proposals solicits projects involving the identification and application of innovative platform technologies, alternative expression systems, novel adjuvants, and other new approaches in vaccinology that could enhance the immunogenicity of candidate tuberculosis or malaria vaccines, extend their in vivo efficacy, reduce the potential for detrimental side effects, simplify production, increase stability, facilitate delivery, or otherwise improve prospects for their ultimate clinical utility. Much of this technology and expertise resides in private industry, and it is the specific intent of this Request for Proposals to provide incentive for industry involvement in the development of malaria and tuberculosis vaccines. It is also the intent of this Request for Proposals to stimulate new and innovative approaches to develop vaccines against malaria and tuberculosis, not to provide increased support for ongoing studies of vaccine approaches already under development. Successful offerors will be recognized as partners in NIAID_s vaccine development efforts, and in coordination with NIAID program staff may access other relevant Institute programs as necessary to accelerate progress. It is anticipated that up to 10 Part A awards will be made for a period of two years for an initial pilot phase to establish technical merit and feasibility, and to determine the quality of performance of the contractor. If clear milestones are met, the Government anticipates that up to 4 contracts may transition in an expedited manner to a more extensive developmental phase (an optional Part B) which will continue in years three through five of the potential period of performance . The decision as to whether a project is ready for transition to Part B will be made by the Government, based on successful completion of milestones proposed by the offeror and negotiated with NIAID prior to contract award. Proposals for Part A or Part B alone will not be accepted. Each proposal shall address development of a single vaccine for a single disease, although, for the same pathogen, the vaccine may incorporate multiple antigens. These awards will be cost-reimbursement, completion type contracts. RFP NIH-NIAID-DMID-02-15 will be available electronically on or about May 17, 2001 and may be accessed through the NIAID Contract Management Branch (CMB) Home Page using the following address and instructions: NIAID CMB Home Page (via the World Wide Web) may be accessed using http://www.niaid.nih.gov/contract. Once you are at the NIAID Contracts Page, select "current RFPs" and then select "RFP-NIH-NIAID-DMID-02-15._ Please note that the RFP for this acquisition has been revised to include only the Work Statement, deliverable and reporting requirements, special requirements and mandatory qualification, if any, the Technical Evaluation Criteria, and the proposal preparation instructions. All information required for the submission of an offer will be contained in the electronic RFP package. Following proposal submission and the initial review process, Offerors comprising the competitive range will be requested to provide additional documentation to the Contracting Officer. Responses to this RFP will be due on September 17, 2001. Any responsible offeror may submit a proposal that will be considered by the Government. This advertisement does not commit the Government to award a contract. Point of Contract: Glynis Fisher, Contract Specialist Electronic mail address: gfisher@niaid.nih.gov Telephone: 301-496-3699 FAX: 301-480-5253 No collect calls will be accepted.

Web Link

Visit this URL for the latest information about this (http://www.eps.gov/cgi-bin/WebObjects/EPS.woa/wa/SPF?A=P&P=NIH-NIAID-DMID-02-15&L=3465)

Record

Loren Data Corp. 20010507/ASOL002.HTM (D-123 SN50L1I0)