A -- EVALUATION OF CHEMOPREVENTIVE AGENTS BY IN VITRO TECHNIQUES

Notice Date

March 29, 2001

Contracting Office

National Cancer Institute, Research Contracts Branch, PCPSS, Executive Plaza South, Room 635, Bethesda, Md 20892

ZIP Code

20892

Solicitation Number

MAO-N01-CN-15015-40

Response Due

May 31, 2001

Point of Contact

Dorothy McMillan, Contract Specialist, 301-435-3828

E-Mail Address

Dorothy McMillan (dm308v@nih.gov)

Description

The National Cancer Institute, Division of Cancer Prevention (DCP), Chemoprevention Agent Development Group (CADRG), is interested in evaluating inhibitors or potential inhibitors of any stage of carcinogenesis, in order to identify potential chemopreventive agents against cancer. Such agents are to be further evaluated in appropriate animal efficacy or clinical settings. The CADRG has established a clearly defined integrated plan for evaluation of chemopreventive agents. This plan delineates detailed criteria for classifying the quantity and quality of information that currently exists on any chemopreventive agent and thus defines what additional information and investigations are required to qualify the agent's experimental use in intervention trials of human cancer. The primary purpose of the RFP is to use in vitro methods to screen chemopreventive agents (see Methods in Cell Biology Vol 19(1):1-70, 1997). The object of these studies is to establish the general efficacy of the chemopreventive agent in a battery of in vitro model systems representing different cell substrates. The studies are designed to provide data to help prioritize agents for further development. Recently a battery of such cell assays were validated against animal tumor data (Steele, et al., J. Cellular Biochem. 26S:29-53,1996). This RFP will be available electronically. Those interested in obtaining a copy of this RFP should send their e-mail address to Dorothy McMillan at dm308v@nih.gov and a copy of the RFP will be forwarded electronically. AN AWARD WILL ONLY BE MADE TO A MASTER AGREEMENT HOLDER IN THE IN VITRO MASTER AGREEMENT POOL. The North American Industry Classification System (NAICS) code is 54171. Proposals will only be considered from offerors in the In Vitro pool. Those who are not currently in the In Vitro Master Agreement pool and who wish to be considered for inclusion should consult the Research Contracts Branch website at http://amb.nci.nih.gov under "Current Requests for Proposals" and refer to RFP/N01-CN-85093-40. It is anticipated that the RFP will be available around the middle of April 2001. Questions should be directed, via facsimile or e-mail, to Dorothy McMillan, Contract Specialist, Prevention and Control Contracts Section, Research Contracts Branch, National Cancer Institute, Executive Plaza South, Room 635, Bethesda, MD 20892-7226. Phone: (301) 435-3828; fax: (301) 402-8579; e-mail: dm308v@nih.gov. NO COLLECT CALLS WILL BE ACCEPTED. Numbered Note 26: Based upon market research, the Government is not using the policies contained in Part 12, Acquisition of Commercial Items, in its solicitation for the described supplies or services. However, interested persons may identify to the contracting officer their interest and capability to satisfy the Government's requirement with a commercial item within 15 days of this notice.

Web Link

Research Contracts Branch Current Request for Proposals (http://amb.nci.gov)

Record

Loren Data Corp. 20010402/ASOL003.HTM (W-088 SN50H6K0)