A -- STUDIES TO EVALUATE THE TOXICOLOGIC AND CARCINOGENIC POTENTIAL OF SELECTED CHEMICALS IN LABORATORY ANIMALS FOR THE NATIONAL TOXICOLOGY PROGRAM

Notice Date

March 19, 2001

Contracting Office

National Institutes of Environmental Health Sciences, Research Contracts Branch, DERT, P.O. Box 12874, Building 4401, Research Commons, 79 T.W. Alexander Drive, Research Triangle Park, NC 27709

ZIP Code

27709

Solicitation Number

NIH-ES-01-08!!

Response Due

April 4, 2001

Point of Contact

Point of Contact and Contracting Officer: Marilyn B. Whaley, 919/541-0416!!

Description

The NIEHS is soliciting offers for a contract to evaluate the toxicologic and carcinogenic potential of selected chemicals via dosed feed, dermal, or gavage routes of administration. This project includes 2-year studies of Cresol, 1,2-Dibromo-2,4-Dicyanobutane, Tetrachloroazobenzene and 14-day, 90-day, and 2-year studies of Ginseng and Kava Kava Extract. Multiple studies shall be conducted concurrently. The base contract shall consist of Phase 1 for all five chemicals to include those work activities associated with the determination of bulk chemical purity and identity, and validation of dose formulation/analysis methods, and any health and safety concerns. Upon successful completion of Phase 1, the Government may unilaterally exercise options for the conduct of 14-day, 21-day, 90-day, or 2-year studies specified as Phases 2 through 4. These studies shall be conducted according to the Specifications for the Conduct of Studies to Evaluate the Toxic and Carcinogenic Potential of Chemical, Biological and Physical Agents in Laboratory Animals for the National Toxicology Program dated September 2000. Offerors shall have a working laboratory involved in conducting studies by the required routes of administration in place by the date of proposal submission. The Principal Investigator, Toxicologist, Chemist, Veterinarian, Health and Safety Officer and Quality Assurance Unit Officer shall be employees of the contract laboratory (i.e., not consultants or subcontractors). The daily interaction and constant coordination of efforts needed amongst these discipline areas throughout the in-life portion of the studies makes it critical that they be physically and organizationally together. Award of one cost-reimbursement, completion type contract on December 28, 2001 on an open competition basis is contemplated as a result of this solicitation. The estimated level of effort is 1,505 labor hours for the base contract and 116,160 labor hours for all options. The estimated period of performance is approximately nine months for the base contract and four years eight months if all options are exercised. Interested organizations should request either a streamlined or full RFP package. If no selection is made, a streamlined version of the RFP will be provided, which will include only the Statement of Work, deliverables and reporting requirements, special requirements, mandatory qualifications, and technical evaluation criteria. After examination of these documents, any organization interested in responding to this RFP must request the entire RFP by written, telephonic ((919) 541-0416), telefax request ((919) 541-2712), or e-mail request (whaley@niehs.nih.gov) . The electronic version of the CBD synopsis and the RFP (which will be available on or about April 4, 2001 without the NTP specifications) is available on the Internet at: http://www.niehs.nih.gov/dert/rcb/rfp.htm . All responsible sources may submit a proposal which shall be considered by the Agency. Expected release date of the RFP is April 4, 2001 with proposals due June 04, 2001.*****

Record

Loren Data Corp. 20010321/ASOL008.HTM (W-078 SN50G605)