A -- TOOLS FOR INSERTIONAL MUTAGENESIS IN THE MOUSE (SBIR-STTR

Notice Date

February 1, 2001

Contracting Office

Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, 6001 Executive Blvd, Rm 3105 (MSC 9543), Bethesda, MD, 20892-9543

ZIP Code

20892-9543

Solicitation Number

SBIR-STTR-RFA-DA-01-012

Response Due

April 11, 2001

Point of Contact

John Hamill, Chief Contracting Officer, NIDA, Phone (301) 443-6677, Fax (301) 443-7595, Email jh148m@nih.gov

E-Mail Address

John Hamill (jh148m@nih.gov)

Description

This Request for Applications (RFA) solicits grant applications for development of tools and techniques for the establishment of random and targeted sequence-tagged insertion libraries of embryonic stem (ES) cells that can be used to generate mutant mice in which the expression of the tagged gene could be controlled temporally and spatially. The development of such a resource for wide distribution to the scientific community would make it possible to scan the sequence database for any gene of interest and order the corresponding targeted ES cell line. Ideally, the insertional mutagenesis system developed would permit a wide range of genetic analyses and manipulations, including enhancer-trapping, conditional knockouts, conditional expression or overexpression, etc. It also would permit the larger community of investigators to utilize genomic resources efficiently. Full project description is available on http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-01-012.html. Contact point is Dr. Rebekah Rasooly on (301)443-6300.

Web Link

Visit this URL for the latest information about this (/cgi-bin/WebObjects/EPS.woa/wa/SPF?A=P&P=SBIR-STTR-RFA-DA-01-012&L=3067)

Record

Loren Data Corp. 20010205/ASOL007.HTM (D-032 SN50C4T5)