A -- EVALUATION OF CHEMOPREVENTIVE AGENTS BY IN VITRO TECHNIQUES

Notice Date

January 26, 2001

Contracting Office

National Cancer Institute, Research Contracts Branch, PCPSS, Executive Plaza South, Room 635, Bethesda, Md 20892

ZIP Code

20892

Solicitation Number

MAA-N01-CN-85093-40

Response Due

March 12, 2001

Point of Contact

Dorothy McMillan, Contract Specialist, 301-435-3828

E-Mail Address

Dorothy McMillan (dm308v@nih.gov)

Description

The Chemoprevention Branch of the Division of Cancer Prevention (DCP) National Cancer Institute, National Institutes of Health (NIH), is expanding the existing Master Agreement Pool for Evaluation of Chemopreventive Agents by In-Vitro Techniques. Screen and evaluate the activity of chemopreventive agents in various in vitro assays relating to the inhibition of cell transformation. Agents with potential chemopreventive activity are identified by epidemiologic surveys, initial laboratory (experimental) findings, observations in the clinical setting, or structural homology with agents having known chemopreventive activity. A rigorous and systematic evaluation of these candidate agents is necessary before their efficacy can be examined in clinical trials for cancer prevention. In vitro screening and evaluation techniques measuring the ability of these chemopreventive agents to inhibit transformation provides a relatively rapid and efficient means of qualifying these agents for further evaluation for the prevention of cancer in humans. Recent progress in the in vitro systems has led to the development of cell culture models and techniques which make possible an evaluation of the effects of various substances on cell transformation. Master Agreements will be awarded to all respondents whose technical proposal is considered acceptable. The Master Agreement award is non-monetary and is exclusively for the purpose of compiling a pool of contractors who are pre-qualified to perform services to perform Evaluation of Chemopreventive Agents by In-Vitro Techniques. Master Agreement holders receiving a contract award will be selected through this pool, based on technical merit and on budgetary considerations for specific workstatements. Any MA awarded as a result of this solicitation will be in effect from the effective date to October 30, 2002. This solicitation will be open for the duration of the existing MA pool with due dates for receipt of proposals annually, MARCH 12,(or the next business day) of each year. All responsible sources meeting these criteria are encouraged to submit a proposal and a sample requirement to be considered by the NCI. ALL MASTER AGREEMENT HOLDERS ALREADY IN THE EXISTING MASTER AGREEMENT POOL NEED NOT RESPOND TO THIS ANNOUNCEMENT. The RFP may be accessed through the Research Contracts Branch RFP page by using the Internet address below. http://amb.nci.nih.gov/appl/rfp/rfps_published.jsp It is the offerors responsibility to monitor the Internet site for the release of this solicitation and amendments, if any. POTENTIAL OFFERORS WILL BE RESPONSIBLE FOR DOWNLOADING THEIR OWN COPY OF THE SOLICITATION AND ANY ADMENDMENTS. Point of contact: Dorothy McMillan, Contract Specialist, NCI, RCB, PCPSS, 6120 Executive Boulevard, Executive Plaza South, Room 635, Rockville, MD 20852; Phone 301-435-3828; Fax: 301-402-8579. Electronic mail address: dm308v@nih.gov. All requests should reference the RFP No. N01-CN-85093-40. No collect calls will be accepted. Numbered Note 26: Based upon market research, the Government is not using the policies contained in Part 12, Acquisition of Commercial Items, in its solicitation for the described supplies or services. However, interested persons may identify to the contracting officer their interest and capability to satisfy the Government's requirement with a commercial item within 15 days of this notice.

Web Link

Research Contracts Branch Current Request for Proposals (http://amb.nci.nih.gov/appl/rfp/rfps_published.jsp)

Record

Loren Data Corp. 20010129/ASOL007.HTM (W-025 SN50B916)