National Institutes of Health, National Heart, Lung, and Blood Institute, Contracts Operations Branch, 6701 Rockledge Drive, Room 6100, MSC 7902, Bethesda, MD 20892

A -- THE SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM OF THE U.S. PUBLIC HEALTH SERVICE SOL PHS 2001-1 DUE 110300 POC Office of Extramural Programs, Office of Extramural Research (301) 435-2688 WEB: National Institutes of Health's "Small Business Funding, http://grants.nih.gov/grants/funding/sbir.htm. National Institutes of Health, Bethesda, MD 20892 and Centers for Disease Control and Prevention, Atlanta, GA 30305 are soliciting proposals from small business concerns that possess the research and development (R&D) expertise to conduct innovative research that will contribute toward meeting the program objectives of the agencies. A SOLICITATION OF THE PUBLIC HEALTH SERVICE FOR SMALL BUSINESS INNOVATION RESEARCH CONTRACT PROPOSALS [PHS 2001-1], with a closing date of November 3, 2000 for receipt of proposals, is or soon will be available electronically through the National Institutes of Health's "Small Business Funding Opportunities" (NIH SBIR/STTR) home page at http://grants.nih.gov/grants/funding/sbir.htm on the World Wide Web. The SBIR/STTR Phase I Contract Solicitation will only be available via electronic means. Printed copies of the solicitation will not be distributed. Potential proposers are encouraged to check the NIH SBIR/STTR home page for updates on the program. Any updates or corrections to the solicitation will be posted there. Included in the Solicitation is a "Fast-Track" initiative. Fast-Track is a parallel review option available to those small business concerns (offeror organizations) whose proposals satisfy additional criteria that enhance the probability of the project's commercial success. Fast-Track offers two major advantages: (1) concurrent peer review of both Phase I and Phase II projects and (2) minimal or no funding gap between Phase I and Phase II. A "Product Development Plan Appendix" must accompany the Phase II proposal. The SBIR program, which was initiated in 1982, was reauthorized through fiscal year 2000 by the "Small Business Research and Development Enhancement Act of 1992" (Public Law 102-564, dated October 28, 1992). A bill (H.R. 2392) to amend the Small Business Act to extend the authorization for the SBIR Program through FY 2008 is pending. The purposes of the Act are to: (a) expand and improve the SBIR program; (b) emphasize increased private sector commercialization of technology developed through federal R&D; (c) increase small business participation in federal R&D; and (d) foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in the SBIR program. For purposes of the SBIR program, a "small business concern" is any business concern that: (a) is independently owned and operated; (b) is not dominant in the field of operation in which it is proposing; (c) has its principal place of business located in the United States; (d) is organized for profit; and (e) has, including its affiliates, no more than 500 employees. Following are the research topics identified in the PHS SBIR Contract Solicitation [PHS 2001-1]: NATIONAL INSTITUTES OF HEALTH (NIH) National Institute on Alcohol Abuse and Alcoholism (NIAAA): Search of Human Heart Genes Differentially Expressed Following Moderate Alcohol Consumption/Exposure (DBR); National Cancer Institute (NCI): Isolation of Natural ProductsUsing Super Critical Fluid Technology; National Institute of Child Health and Human Development (NICHD): Development of A Web-Based Resource of Rehabilitation Engineering Solutions; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): Assays for Identification of High Risk Individuals for the Development of Insulin Dependent Diabetes (IDDM); Transplantation of Human Islets or Beta Cells; Improved Methods for Production of Clinical Gene Therapy Vectors for Diseases of Interest to NIDDK; New Noninvasive Body Iron Test; Mechanical Approaches to Achieving Euglycemia; Measurement of Pancreatic Beta-Cell Mass or Inflammation in the Diabetic Patient; Generation of cDNA Libraries from Hematopoietic Lineages; Development of Arrayed Libraries and Bio-informatics for Use in cDNA Microarrays; mRNA/cDNA Standard for Microarray Experiments; Detection and Assessment of Urologic and Renal Diseases; Minimally Invasive Evaluation of Urolithiasis; Methods To Enhance Procurement and Rapid Utilization of Human Pancreata for Islet Isolation and/or Transplantation; Prospective Identification and Purification of Stem/Progenitor Cells from the Pancreas; National Institute on Drug Abuse (NIDA): Drug Supply Services Support; Chemical Libraries for Drug Development; Prevention Training; Development of Science Education Materials or Programs; Medicinal Chemistry Design and Synthesis of Treatment Agents for Drug Abuse; High Performance Chemistry Directed Analog Synthesis; Dosage Form Development; Develop Drug Abuse Screening/Assessment and Intervention for Youth for Primary Care/Managed Care Providers; Develop New Technologies for Drug Abuse Prevention Delivery: Translation of Empirically Validated Prevention Strategies and Programs into New Technologies; Instrument Development for Assessing Community Factors that Affect Drug Use Consequences; Develop Methods for Gathering Data and Completing Social Network Analysis in Drug Abuse Prevention; Novel Drug Delivery System for the Mouse; High-throughput Screening of Functional Activity of Proteins Using Biosensor-based Technology; Methods for Detecting Chemically Induced Mutations in Mouse Embryonic Stem Cells; Fluorescent Probes; National Institute of Environmental Health Sciences (NIEHS): Development of Genetically-altered Rodent Models for Toxicity and Carcinogenicity Studies; Development of Surrogate Biomarkers for Safety Evaluation of Chemicals; Development of Alternatives to Animals for Toxicity Testing; Mouse Model for Prostate Cancer; Three-Dimensional Atlas of Mouse Anatomy/Pathology; Development of a Database of Genetic Alterations from Environmental Chemicals; Development of a Loss of Heterozygocity Assay for Determining the Mutagenic Basis for Tumor Induction; National Institute of Mental Health (NIMH): Development of New Dissemination Tools for the Delivery of Empirically-Based Psychosocial Interventions; Development of a Web Site on Resources for Suicide Prevention; Multimedia Assessment and Remediation for Informed Consent; New Methods for Rating Patients, TrainingRaters, and Assessing Reliability; Electronic Source Documents; National Institute of Neurological Disorders and Stroke (NINDS): NIRS Device Development for Cerebral Monitoring in the Infant and Child; Development of Systems to Express Functional Eukaryotic Membrane Proteins For Crystallization; Development of Pain Model Systems and Assessment Tools. CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC) National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP): Family-Based Detection of Hemochromatosis. National Immunization Program (NIP): Technologies to Overcome the Drawbacks of Needles and Syringes; Operations Research for Expanded Vaccine Selection Algorithm. The PHS SBIR Contract Solicitation PHS 2001-1, including proposal forms, is or soon will be available electronically through the National Institutes of Health's "Small Business Funding Opportunities" home page at http://grants.nih.gov/grants/funding/sbir.htm on the World Wide Web. Posted 07/24/00 (W-SN477950). (0206)

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