National Institute of Child Health and Human Development, Contracts Management Branch, 6100 Bldg., Suite 7A07, 6100- Executive Blvd MSC 7510, Bethesda, MD 20892-7510

A -- SYNTHESIS OF 1 TO 3 KG AND 10 TO 15 KG BATCH SIZES OF 7 ALPHA-METHYLESTRONE SOL CPR-SS-2000-04 DUE 061500 POC Charles W. Grewe, Contracting Officer, (301)496-4611 E-MAIL: Contracts Management Branch, NICHD, nichdcmb@mail.nih.gov. The Contraception and Reproductive Health Branch, Center for Population Research, National Institute of Child Health and Human Development, National Institutes of Health, is seeking to identify organizations with experience and capabilities in steroid synthesis. Synthesis of 1 to 3 kg and 10 to 15 kg batch sizes of 7 alpha-methylestrone are desired, following the literature (Wieland P and Anner G, Helv. Chim. Acta 50, 289 -- 296 (1967)) including patent procedures (U.S. Patent 3,318,929, May 9, 1967 to CIBA Corp. ). It is anticipated that optimization is required for the best overall yield for the literature or patent procedures. The final product must have >98% purity. A stereoselective total synthesis of racemic 7 alpja-methylestrone should not be considered for this purpose. Organizations should have in house analytical capabilities for the determination of chemical and optical purity including the presence of impurities as well as solvents. Organizations interested in performing such work should submit a summary of their capabilities and experience with similar projects, including personnel and equipment which could be assigned to the project. All organizations who have the capabilities to meet this need, should submit a brief (less than 10 pages) Capability Statement. Three copies should be sent to: Mr. Charles W. Grewe, Contracting Officer, NICHD/OAM/CMB, Room 7A07, 6100 Executive Blvd., Bethesda, Maryland 20892. However, e-mail and Fax responses are also acceptable. E-Mail -- nichdcmb@mail.nih.gov or Fax -- (301) 402-3676. Responses are due COB 6/15/2000. This notice is NOT a request for proposals (RFP). A determination to issue an RFP will be based, in part, on responses received from this notice. Future information on this topic may be found at the NICHD Contracts Management Branch Home Page -- http://www.nichd.nih.gov/oam-cmb/.***** Posted 05/18/00 (W-SN456413). (0139)

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