Loren Data Corp.

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COMMERCE BUSINESS DAILY ISSUE OF MARCH 16,2000 PSA#2558

Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94550

A -- LAWRENCE LIVERMORE NATIONAL LABORATORY SEEKS PARTNERS TO COMMERCIALIZE A LASER INDUCED PROTON SOURCE A -- LAWRENCE LIVERMORE NATIONAL LABORATORY SEEKS INDUSTRIAL PARTNERS TO COMMERCIALIZE A LASER INDUCED PROTON SOURCE SOL 00-018 DUE 041400 POC Industrial Partnerships and Commercialization (925) 423-3139 The Lawrence Livermore National Laboratory (LLNL), operated by the University of California under contract with the U.S. Department of Energy is seeking industrial partners and collaborators for the commercialization and further development of a laser induced proton source. LLNL scientists have developed a proton source that can yield high-energy proton beams in a compact, flexible and relatively inexpensive fashion that is driven by a high intensity tabletop laser. The laser induced proton source device is compact, with sizes ranging as small as a tabletop. The proton beam has characteristics which are expected to allow precise tailored penetration depths in a target such as the human body. It may be possible that as little as a single dose burst of protons from this device may be sufficient for well-localized irradiation of cancerous tissues for cancer proton radiation therapy. An alternate configuration produces protons of a few MeV from a target located at the tip of glass fiber, giving rise toa "proton needle". The "proton needle" has potential applications for catheter fed or surgically introduced cancer radiation treatments. Additional applications include proton spectroscopy evaluation and material treatment. LLNL has advanced expertise in the technologies critical to the development of laser induced proton sources. LLNL's expertise includes femtosecond pulse length laser systems with resultant petawatt powers, fiber optical delivery systems, radiation measurement, and the Peregrine radiation dose modeling software. LLNL has core scientific and intellectual property background, including patent applications with potential international rights, on this project. Companies interested in working with LLNL to commercialize the technology should provide a written statement of interest that includes a description of corporate capability relevant to commercialization of the technology and basic corporate information. Respondents are encouraged to provide ancillary documentation such as annual reports, corporate resumes, and technical publications. THIS IS NOT A PROCUREMENT. All Letters of Interest must be received within 60 days of this announcement. Please send Letters of Interest to Eddie Scott, Business Development Specialist, Lawrence Livermore National Laboratory, 7000 East Avenue, Mail Stop L-795, Livermore, CA 94550-9234, Attention: CBD-00-018. Posted 03/14/00 (W-SN434416). (0074)

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