National Cancer Institute, Research Contracts Branch, PCPSS, Executive Plaza South, Room 635, Bethesda, Md 20892

A -- PRECLINICAL EVALUATION OF INTERMEDIATE ENDPOINTS AND THEIR MODULATION BY CHEMOPREVENTIVE AGENTS SOL MAA RFP N01-CN-85052-72 DUE 020100 POC Jacqueline Ballard, 301-435-3795 WEB: http://amb.nci.nih.gov/ncics/rfps_published.asp., http://amb.nci.nih.gov/ncics/rfps_published.asp.. E-MAIL: Ballard, Jacque (NCI), ballardj@mail.nih.gov. AMENDMENT 1 -- Effective 10/20/1999: OPEN ELECTRONIC ANNUAL MASTER AGREEMENT ANNOUNCEMENT NO. RFP N01-CN-85052-72 (Preclinical Evaluation of Intermediate Endpoints and their Modulation by Chemopreventive Agents This RFP is amended. Please review the Amendments. Offerors are responsible for routinely checking this internet website for any possible solicitation amendments that may be issued. No additional notification of any amendments will be provided. Proposal revised due date : February 1, 2000 The Division of Cancer Prevention (DCP), National Cancer Institute (NCI), National Institutes of Health(NIH), intends to expand the existing Master Agreement (MA) pool for "Preclinical Evaluation of Intermediate Endpoints and Their Modulation by Chemopreventive Agents". ALL MA HOLDERS ALREADY IN THE EXISTING MA POOL NEED NOT RESPOND TO THIS ANNOUNCEMENT. Offerors selected for award of a MA may be solicited to provide qualified personnel, materials and supplies, equipment and facilities to carry out orders issued. Offerors should be capable of performing animal cancer model studies of biomarkers and intermediate endpoints that might be used in human clinical trials in order to examine in detail the biomarker modulating effects of selected chemopreventive compounds. The emphasis will be on efficient studies aimed at providing more quantitative and more validated intermediate endpoints for future human clinical trials. Individual work requirements (Master Agreement Orders (MAOs)) will be issued during the period of performance and awarded based upon competition among members of the MA Pool. The MA mechanism is a pre-qualification process to enable qualified sources to compete for and perform future contracts which will be awarded based on Request for Proposals (RFPs). The MA award is non-monetary and is exclusively for the purpose of compiling a pool of contractors who are pre-qualified to perform services for efficacy studies. The obligation of funds shall be accomplished solely through the award of contracts (MAO). Any MA awarded as a result of this solicitation will be in effect from the effective date to December 31, 2002. This solicitation will be open and remain on the NCI's Website for the duration of the existing MA Pool with a revised due date for receipt for proposals February 1 (or the next business day) of each year. All responsible sources meeting these criteria are encouraged to submit a proposal and a sample requirement to be considered by the NCI. The RFP may be accessed through the Research Contracts Branch Home Page by using the following Internet address: http://amb.nci.nih.gov/ncics/rfps_published.asp. It is the offeror's responsibility to monitor the above internet site for the release of this solicitation and amendments, if any. POTENTIAL OFFERORS WILL BE RESPONSIBLE FOR DOWNLOADING THEIR OWN COPY OF THE SOLICITATION AND AMENDMENTS. (Hard copies will be available only upon individual request). Please contact: Jacqueline Ballard, Contracting Officer, NCI, AMB, PCPSS; 6120 Executive Boulevard, Executive Plaza S., Room 635, Rockville, MD. 20852; Email address: ballardj@mail.nih.gov.; Fax 301-402-8597. No collect calls will be accepted. Posted 10/20/99 (W-SN393300). (0293)

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