U. S. Environmental Protection Agency, Contracts Management Division (MD-33), Attn: ORDSC, Research Triangle Park, NC 27711

A -- GASTROINTESTINAL ABSORPTION STUDIES OF CHLORPYRIFOS USING A SINGLE-PASS INTESTINAL PERFUSION TECHNIQUE -- ADMENDMENT #1 SOL UZG211 DUE 091499 POC Pamela E. Smith (919) 541-0635, Purchasing Agent UZG211 previously posted in the CBDNet on August 27, 1999 has been amended. Amendment # 1, is issued to the above combined synopsis/solicitation for the purchase of Gastrointestinal Absorption Studies of Chlorpyrifos Using A Single-Pass Intestinal Perfusion Technique. The following is a correction to the statement. 3) Use known correlations, if they exist, between rat and human to understand the implications of the experiments to permeability in human intestines. 4) Examine the applicability of physicochemical correlations to predict the permeability of organophosphate pesticides or their extent of absorption. STATEMENT OF WORK: The contractor shall investigate the permeability of the intestinal wall of laboratory animals to chlorpyrifos and will determine whether or not there is regional variability in this parameter. Posted 09/01/99 (W-SN375433). (0244)

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