National Institute on Drug Abuse, Division of Intramural Research, PO Box 5180, Baltimore, MD 21224-0180

A -- AFFYMETRIX GENECHIP ARRAYS (MU6500 SET) SOL NIDA-99-JCA006 DUE 072999 POC Janes C. Amend Tel. 410-550-1637, Fax. 410-550-3146 NIH/NIDA/IRP in Baltimore, Md. requires Affymetrix GeneChip arrays (MU6500 SET containing 20 antisense arrays: 5 x mu6500 sub a,b,c,d arrays)for the Affymetrix GeneChip expression analysis monitoring system. This system is used for finding and studying genes related to drug abuse. Probe arrays capable of detecting expression levels of detecting 5-10 thousand human or murine genes will be required for genetic studies related to drug abuse research. It is essential that each probe cell have 10 or greater copies of a given probe to be able to detect low levels of expression. NIDA/IRP studies the structure and regulation of genes involved in nervous system function and drug action. These effects are on specific neurotransmitter systems such as the dopaminergic or opiatergic systems. The purpose of this project is to find a gene or genes related to drug abuse, determine how that gene is affecting the addictive process and ultimately design new pharmaceutical agents for treatment of drug addiction. The Molecular Neurobiology Section has purchased a GeneChip Analysis System from Affymetrix Inc. which will allow us to search large portions of human, murine, and yeast chromosomes for genes which are involved in drug abuse. This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR Subpart 12.6, as supplemented with additional information included in the notice. This announcement constitutes the only solicitation. Proposals are being requested and written solicitation will not be issued. Solicitation NIDA-99-JCA006 herein is a Request for Quotation (RFQ). (The solicitation document, preovisions and clauses herein are those in effect through FAC 90-46.) The proposed solicitation contained herein is restricted to Small Business Concerns. Delivery of the procured biological material shall be FOB DESTINATION, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, Md. #21224. The Government anticipates to award a Firm Fixed-Price contract. The following factors will be used to evaluate offers in descending order of importance: 1) price, 2) technical capability of item offered to meet the government's requirements, 3) past performance. Award will be based on the lowest price, technically acceptable offer from a vendor with a satisfactory past performance record. FAR 52.212-1 Instruction to Offerors-Commercial Items, and FAR 52.212-4 Contract Term and Condition-Commercial Items applies to this acquisition. The offeror shall submit a completed copy of FAR 52.212-3 Offeror Representation and Certifications-Commercial Items with its offer. Direct questions or inquiries referencing the RFQ Number by return FAX. (410-550-3146). Proposals shall be received by the NIDA, 5500 Nathan Shock Drive, Bldg C, Baltimore, Md. #21224 no later than close of business of the fifteenth day from the date this announcement first appears in the CBD. Offerors are reminded that this announcement constitutes the only solicitation and NO WRITTEN RFQ WILL BE ISSUED. Offeror shall submit a price proposal by return FAX. Posted 07/07/99 (W-SN351128). (0188)

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