Environmental Protection Agency, National Health Environmental Effects Research Laboratory (MD85), Research Triangle Park, NC 27711-0001

A -- EPIDEMOLOGIC STUDIES TO DETERMINE THE FRACTION OF GASTROINTESTINAL ILLNESS ATTRIBUTABLE TO DRINKING WATER IN SEATTLE, WA SOL HSD-99-001 DUE 081399 POC Margaret Mann (919)541-4896 WEB: HSD-99-001, http://www.epa.gov/nheerl/solicitations/hsd. E-MAIL: HSD-99-001, Mann.Margaret@epamail.epa.gov. The US Environmental Protection Agency (EPA), Office of Research and Development (ORD), National Health and Environmental Effects Research Laboratory (NHEERL), Human Studies Division (HSD), Epidemiology and Biomarkers Branch (EBB), located in Chapel Hill, NC is requesting 20 page research assistance preapplications to conduct epidemiologic studies to determine the fraction of gastrointestinal illness attributable to drinking water in Seattle, Washington. Since the amount of waterborne disease in a population can most directly be estimated by determining the rate of gastrointestinal illness in the community and multiplying this by an estimate of the percentage of illness that is attributable to water, this study will involve measuring both of these parameters in a population and by community surveillance. In addition to gastrointestinal illnesses, the applicants will be encouraged to consider the list of microbial organisms listed on the Contaminant Candidate List (CCL) and propose possible studies to evaluate the role of drinking water in their transmission. The CCL is available on EPA's web page at http://www.epa.gov/OGWDW/ccl/cclfs.html. Based on the availability of funds and the research proposed, up to $900,000 over a four-year period may be availableto support the research efforts beginning in January 2000. An independent peer review panel will evaluate all preapplications. The research preapplications must be received by August 13, 1999. The selected preapplication(s) will be asked to submit a full application along with EPA forms for an assistance agreement, by November 1, 1999. Eligible applicants include members of nonprofit research organizations. Nonprofit research organizations are defined as institutions of higher education, hospitals, and other non-profit organizations. Statutory authority for EPA funding of the specified research is authorized in the Safe Water Act, as amended in 1996. Interested applicants must be eligible to receive Federal Assistance under this statutory authorities and the Code of Federal Regulations (CFR) Part 30-General Regulation for Assistance Programs, and Part 40-Research and Demonstration Grants. ONLY NONPROFIT RESEARCH ORGANIZATIONS ELIGIBLE TO RECEIVE FEDERAL ASSISTANCE UNDER THESE ACTS SHOULD SUBMIT APPLICATIONS. The solicitation and any subsequent amendments will be available via the Internet Worldwide Web at http://www.epa.gov/nheerl/solicitations/hsd. Telephone and FAX requests will not be honored. It will be your responsibility to frequently check the same site where the solicitation is posted for any amendments. Posted 06/28/99 (W-SN347988). (0179)

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