National Institutes of Environmental Health Sciences, Research Contracts Branch, DERT, P.O. Box 12874, Building 4401, Research Commons, 79 T.W. Alexander Drive, Research Triangle Park, NC 27709

A -- PATHOLOGY SUPPORT FOR THE NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES. SOL NIH-ES-99-34 DUE 070699 POC Howard Hill, Contract Specialist, (919)541-4971, Allan C. Benton, Contracting Officer, (919)541-4670. WEB: NONE, NONE. E-MAIL: NONE, NONE. The National Institute of Environmental Health Sciences (NIEHS), National Institute of Health (NIH), is soliciting proposals from offerors having the capability and facilities to perform the following: Work Assignment 1. Pathology Working Group (PWG) Review: The Contractor shall conduct PWG reviews (usually conducted at the NIEHS) for NTP prechronic and chronic studies and for in-house NIEHS studies. This encompasses a thorough review of all pathology and toxicology data, target tissues, potential treatment-related lesions and other selected tissues and lesions from a study by an appropriately trained and qualified pathologist, with subsequent selection and preparation of relevant data for a PWG panel review in consultation with an NIEHS pathologist assigned to the study. Work Assignment 2. Necropsy, Histology, and Histopathological Interpretation: The Contractor shall conduct complete necropsies that may include blood collection, whole body or organ perfusion for ultrastructural examinations, radiography or rapid freezing of various tissues that may include post fixation trimming of collected tissue samples in preparation for tissue processing and paraffin embedding. Work Assignment 3. Data Entry: Pathology data from the histopathological evaluation, and the peer review (PWG chairperson's review) shall be entered into a special computer program. Work Assignment 4. Evaluation of Pathology Materials: The Contractor shall perform wet tissue examination and inventory including verification of animal identification, tissue accountability, gross lesion identification and description, assessment of quality and thoroughness of tissue trimming, and slide/block and wet tissue match-up. This project will cover a five year period including 3 Options-Work Assignments. The Government estimates that the contract shall require approximately 2 professional person-years and 2.5 technical person-years (per year) in addition to 1.5 persons years for administrative and clerical support. All requests must reference RFP No. NIH-ES-99-34 and must be directed to the office listed above. All responsible sources may submit a proposal which shall be considered by the Agency. Posted 05/04/99 (W-SN327673). (0124)

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