National Institutes of Health, Office of Procurement Management, 6011 Executive Blvd., Rockville, Maryland 20892-7260

66 -- PROTEIN BIOLOGY SYSTEM II SOL 263-99-P(BN)-0028 DUE 042199 POC Foteni T. Tiffany, Contracting Officer, 301-402-3079 This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. The solicitation number is 263-99-P-(BN)-0028 and is issued as a Request for Proposal (RFP). The solicitation/contract will include all applicable provisions and clauses in effect through FAC 97-10. The standard industrial code (SIC) is 3826 and the business size is 500 employees. The National Institutes of Health, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, has a requirement to acquire one (1) Protein Biology System II. The NIH intends to contract with Ciphergen Biosystems, 490 San Antonio Road, Palo Alto, CA 94306, the only known source for this particular equipment. The equipment shall be capable of the following unique performance specifications: 1. The system shall perform surface-enhanced affinity capture (SEAC) using surface-enhanced laser description/ionization (SELDI) for the quantitative analysis of trace components (at low femtomole levels) directly from biological samples. 2. The system shall perform analyses of protein chips comprising arrays of antibodies to capture diagnostic marker proteins directly from biological specimens for identification based on molecular mass. 3. The system shall perform the analysis of one microliter of unfractionated biological fluid as well as extract to provide a protein retentate map with a minimum of 300 features (peaks). 4. The system shall purify proteins from complex biological mixtures directly on the protein chip surface. 5. The system shall perform on-chip molecular processing, including protein purification, peptide mapping, C-terminal, microsequencing and post-translational modification analysis. 6. The system shall be capable of performing surface-enchanced neat desorption (SEND) for the analysis of low molecular mass analytes from 0-1,000 daltons. 7. The system shall provide experimental data in gel-view display format for direct comparison with gel electrophoresis data. 8. The system shall provide automated peak integration (digitization) with peak map display and comparison formats for differential protein display. 9. The system shall perform analyses of protein chip molecular arrays in a fully automated mode requiring a minimum of 100 addressable regions per 2mm of surface area. 10. The contractor shall provide a YEAR 2000 Warranty for each hardware, software, and firmware product delivered under this contract. The contractor shall be able to accurately process the data (including, but not be limited to, calculating comparing, and sequencing) from, into, and between the twentieth and twenty-first centuries and for the YEAR 2000 and leap year calculations. Nothing in this warranty shall be construed to limit any rights or remedies the Government may otherwise have under this contract with respect to defects other than YEAR 2000 performance. The Government anticipates the award of of an Indefinite Delivery, Indefinite Quantity contract, with a minimum of one (1) system and a maximum of thirty-five (35) systems, which shall be for Government-wide usage. The period of performance shall be for twelve (12) months with four (4) successive renewable twelve (12) month options. Deliveries shall be made FOB Destination within consigneee's premises to the specified address(es). The Government desires the initital delivery of one (1) Protein Biology System II within sixty (60) calendar days after date of contract award, for delivery to the National Institute of Allergy and Infectious Diseases. Thereafter, additional instruments will be ordered as requested by the Government. If the offeror is unable to meet the desired delivery schedule, it may, without prejudicing evaluation of its offer, propose a delivery schedule. However, the offeror's proposed delivery schedule must not extend the delivery period beyond the Government'sREQUIRED delivery schedule of ninety (90) calendar days after placement of order. The Government will evaluate based on F.O.B. Destination and acceptance at Bethesda, Maryland, and the requirements of FAR 52.214-21 "Descriptive Literature" apply. Proposals/Information provided must demonstrate the equipment's ability to meet the specifications described herein. A completed copy of the provision 52.212-3, Offeror Representations and Certifications-Commercial Items, is required as part of the offer. The clause 52.212-4 Contract Terms and Conditions-Commercial Items applies to this acquisition. The clause at 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders-Commercial Items applies to this acquisition. The Contractor will be paid following delivery, and acceptance of the equipment. The proposed contract action is for supplies or services for which the Government intends to solicit and negotiate with only one source under the authority of FAR 6.302. Interested persons mayidentify to the Contracting Officer their interest and capability to satisfy the Government's requirement with a commercial item within 15 days of this notice. A determination by the Government not to compete with this proposed contract based upon responses to the notice is solely within the discretion of the Government. Information received will normally be considered solely for the purpose of determining whether to conduct a competitive procurement. Address responses to the attention of Ms. Foteni Tiffany at the above address. FAX responses are acceptable at 301/402-3407. Posted 04/02/99 (W-SN315705). (0092)

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