National Cancer Institute, Research Contracts Branch, PCPSS, Executive Plaza South, Room 635, Bethesda, Md 20892

A -- CENTRALIZED CHEMOPREVENTIVE AGENT REPOSITORY AND DRUG CHEMISTRY SUPPORT SOL N02-CN-95016-24 DUE 042999 POC Curtis R. Foust, Contract Specialist, 301-435-3798; Charles Lerner, Contracting Officer, 301-435-3831 WEB: Research Contracts and Acquisition Branch RFP Page, http://amb.nci.nih.gov/rfp.htm. E-MAIL: Curtis R. Foust, foustc@amb.nci.nih.gov. Synopsis The Division of Cancer Prevention of the National Cancer Institute, is seeking a contractor who will provide a centralized source of agents for use in preclinical and clinical studies to perform certain agent-related drug analytical chemistry activities. The Contractor shall: identify sources and procure bulk reagent chemical substances, receive agents from suppliers, store reagents, and provide administrative support as needed for dosage formulation, encapsulation, packaging and labeling, including shipment and accountability to final destinations. Essential activities for the overall operation of this contract include: monitoring stock levels at user locations, inventory control to assure timely reordering, and shipping of agents, maintenance of up-to-date records of shipments, and quality assurance capability such as bulk and formulated agent identity, purity, potency, and shelf life analyses. Agent-related analytical chemistry activities include providing all documentation related to requirements of preparing and updating the Chemistry, Manufacturing, & Control sections of Investigational New Drug applications to the FDA, and/or the equivalent in the form of a Drug Master File. Additional analytical activities include performing specialized analytical and pharmacological tests as required by the FDA or as required to fulfill specialized needs in the drug development process. The organization must possess an Environmental Protection Agency (EPA) Generator of Hazardous Waste permit and any state and local permits (if necessary), for generation and transportation of waste drugs for disposal, storing toxic hazardous substances, and storing and distributing investigational drugs for the life of this contract. At least one pharmacist performing work under the contract shall be concurrently licensed in the state (or District of Columbia ) in which the repository is located. This procurement is a recompetition of an existing contract which expires on September 29, 1999 and is currently being performed by McKesson BioServices, Inc., Gaithersburg, Maryland. The expected duration of this acquisition is five (5) years. The RFP will be released on or about 03/15/1999with proposals due 04/29/1999. THE RFP MAY BE ACCESSED THROUGH THE RESEARCH CONTRACTS AND ACQUISITION BRANCH HOME PAGE BY USING THE FOLLOWING INTERNET ADDRESS: http://amb.nci.nih.gov POTENTIAL OFFERORS WILL BE RESPONSIBLE FOR DOWNLOADING THEIR OWN COPY OF THE SOLICITATION AND AMENDMENTS. Point of contact: Curtis R. Foust, Contract Specialist, Electronic mail address: foustc@amb.nci.nih.gov, Fax (301) 402-8579. No collect calls will be accepted. Posted 02/24/99 (W-SN301934). (0055)

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