Contracts Management Section, National Institute of Dental and Craniofacial Research, NIH, Natcher Building, Room 4AN-44D, 45 Center Drive MSC 6402, Bethesda, Maryland 20892-6402

A -- ROLE OF THYMOSIN BETA-4 IN WOUND HEALING SOL NIH-NIDR-12-98-2R DUE 032699 POC Marion L. Blevins 301 594-0652 The National Institute of Dental and Craniofacial Research has a requirement for the conduct of a controlled Phase I clinical trial of the efficacy of thymosin beta-4 on healing of patients with pressure ulcers. The contractor will be required to recruit a minimum of 40 patients with non-healing, chronic, pressure ulcers of at least three months. The objective of the study is to have thymosin beta-4 tested for its ability to effect wound repair in venous ulcers, which are the most common form of chronic wounds. The Request for Proposal (RFP) will be available on or about February 12, 1999, with a closing date for proposals approximately March 26, 1999. All requests for the RFP must be submitted in writing. Requests may be submitted via facsimile at 301-480-8308. Verbal requests will not be accepted. Posted 01/25/99 (W-SN291001). (0025)

Loren Data Corp. http://www.ld.com (SYN# 0002 19990127\A-0002.SOL)