National Cancer Institute, Research Contracts Branch, PSAS, 6120 Executive Blvd, EPS/Room 638, Bethesda, MD 20892-7227

B -- NATIONWIDE LINKED-REGISTRY DATA TO EXAMINE CANCER RISK AMONG PATIENTS WITH BRONCHIAL ASTHMA SOL RFQ-NCI-90032-NV DUE 011399 POC Debbie Moore, Purchasing Agent, 301-402-4509, Todd Cole, Contracting Officer 301-402-4509 The National Cancer Institute proposes to procure services from the Finnish Cancer Registry, Liisankatu 21 B, Fin-00170 Helsinki, Finland, to examine cancer risk among patients with bronchial asthma. NCI must identify both out-patient and hospitalized asthma patients in a population-based study for complete ascertainment of eligible cohort members and for evaluation of the severity of asthma on cancer risk. In addition, inclusion of long-term (up to thirty or more years) patients is necessary to assess long-term cancer risks. The Finnish Cancer Registry, which offers the aforementioned characteristics, consists of patients diagnosed with bronchial asthma (ICD-7 code 241, ICD-8 code 493 or ICD-9 493) between 1964 and 1997. The cohort members will be followed for cancer outcomes, particulary lung cancer, hematopoietic malignancies, and adenocarcinomas of the esophagus and gastric cardia. The Finnish Cancer Registry is a nationwide population-based registry. The Finnish data are unique with regard to: the size of the cohort with an estimated person-years at risk of over 1.5 million, which allow for detailed analysis cancer outcomes by histologic type and anatomic subsite, including less common cancers such as esophageal and gastric cardia adenocarcinomas. In addition, the Finnish Cancer Registry investigators have experience in conducting large population-based out-patient cohort studies, including an out-patient cohort study of asthma patients. Based on the NCI researcher's knowledge, the Finish linked-registry data is the only known large computerized, population- based data source that include both in-patient and hospitalized asthma patients who can be linked to a population-based cancer registry for long-term follow-up of cancer outcomes. However, if any interested party believes it can meet all of these requirements, it may submit a capability statement to Debbie Moore, 6120 Executive Blvd., Rm. 634, Rockville, MD 20892-7227 by no later than January 13, 1998 at 2PM EST. Information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform the requirement. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No Collect calls will be accepted. Posted 12/23/98 (W-SN283049). (0357)

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