A&MMS (573/90C), Veterans Administration Medical Center, 1601 Archer Road, Gainesville, Florida 32608-1197

B -- SPECIAL STUDY WITH DEPARTMENT OF MEDICINE AT THE UNIVERSITY OF FLORIDA SOL RFP 573-009-99 DUE 112098 POC Marilyn Gray, Contract Specialist, phone 352/374-6007 or FAX# 352/379-7437 This notice is not intended to solicit proposals, but for informational purposes only. The VA Medical Center in Gainesville, Florida intends to negotiate a sole source contract with the University of Florida, Department of Medicine beginning the date of award for one year with two optional years for renewal. The overall objective of this study entitled, Biophysical analysis of marine natural products that mimic the actin-binding properties of gelsolin with the Prinicipal Investigator being Dr. Michael Bubb is to define quantitative aspects of the interaction between marine natural products and actin using biophysical techniques. Time dependent fluorescence anisotropy, fluorescence energy transfer, analytical ultracentrifugation and 3-dimensional molecular modeling will be used to assess on-and off-rates, stoichiometry and structural relationships. The rationale for this proposed study is to identify lead compounds to be developed as anti-tumor agents mimicing the function of the tumor suppressor, gelsolin. In order for this to proceed in a rationale manner, a quantatative comparison of marine natural products must be used to identify similarities and differences between the activities of gelsolin and the activities of each marine natural product under consideration. Authority 6.302. See Note 22. Posted 11/12/98 (W-SN270879). (0316)

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