Director, USAMRAA, 820 Chandler St, Fort Detrick, MD 21702-5014

A -- TREATMENT FOR SKIN INJURY ASSOCIATED WITH EPIDERMOLYSIS BULLOSA (EB) SOL CBD&&&98080002 DUE 110498 POC Patricia M. McAllister, 301-619-7360 The U.S. Army Medical Research and Materiel Command announces a Request for Proposals to augment the Army's in-house scientific endeavors at improving the survivability of soldiers in chemically-contaminated environments. A requirement exists to better understand the mechanism of blister formation following exposure to blistering agents, e.g., sulfur mustard (SM). The pathophysiology of SM-induced injury appears to be similar to that produced by some variants of the naturally occurring disease epidermolysis bullosa (EB). The studies will elucidate the mechanism(s) of vesicle and bullae formation and possible treatment for underlying skin injury associated with EB. The contract will include writing protocols and conducting tests to identify the physiological processes involved, and to investigate preventive measures and treatment strategies. Protocols, studies, and reports shall comply with Good Laboratory Practices (GLP) and Good Manufacturing Practices (GMP) guidelines and applicable government guildines. Proposal guidelines are contained in the U.S. Army Medical Research and Materiel Command Broad Agency Announcement located on the USAMRAA Homepage at www-usamraa.army.mil. To be considered for this program, proposals should be submitted no later than Wednesday, November 4, 1998 and forwarded to U.S. Army Medical Research Acquisition Activity, ATTN: MCMR-AAA, 820 Chandler Street, Fort Detrick, MD 21702-5014. Posted 08/27/98 (W-SN242762). (0239)

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