National Institutes of Health, National Heart, Lung, and Blood Institute, Contracts Operations Branch, 6701 Rockledge Drive, Room 6100, MSC 7902, Bethesda, MD 20892

A -- A SOLICITATION OF THE PUBLIC HEALTH SERVICE FOR SMALL BUSINESS INNOVATIVE RESEARCH CONTRACT PROPOSALS SOL PHS 99-1 DUE 110598 POC Office of Extramural Programs, Office of Extramural Research, 301-435-2770 WEB: National Institutes of Health's "Small Business Funding, http://www.nih.gov/grants/funding/sbir.htm. E-MAIL: PHS SBIR/STTR Solicitation Office, a2y@cu.nih.gov. THE SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM OF THE U.S. PUBLIC HEALTH SERVICE SOL [PHS 99-1] DUE 110598 POC Office of Extramural Programs, Office of Extramural Research, (301) 435-2770. National Institutes of Health, Bethesda, MD 20892, Centers for Disease Control and Prevention, Atlanta, GA 30305, and Agency for Health Care Policy and Research, Rockville, MD 20852 of the Public Health Service are soliciting proposals from small business concerns that possess the research and development (R&D) expertise to conduct innovative research that will contribute toward meeting the program objectives of the agencies. A SOLICITATION OF THE PUBLIC HEALTH SERVICE FOR SMALL BUSINESS INNOVATION RESEARCH CONTRACT PROPOSALS [PHS 99-1], with a closing date of November 5, 1998, for receipt of proposals, is or soon will be available electronically through the National Institutes of Health's "Small Business Funding Opportunities" home page at http://www.nih.gov/grants/funding/sbir.htm on the World Wide Web. A limited number of hard copies of the PHS SBIR Contract Solicitation is or soon will be available from: PHS SBIR/STTR Solicitation Office, 13687 Baltimore Avenue, Laurel, MD 20707-5096, phone: (301) 206-9385, fax: (301) 206-9722, e-mail: a2y@cu.nih.gov. Included in the Solicitation is a "Fast-Track" initiative. Fast-Track is a parallel review option available to those small business concerns (offeror organizations) whose proposals satisfy additional criteria which enhance the probability of the project's commercial success. Fast-Track offers two major advantages: (1) concurrent peer review of both Phase I and Phase II projects and (2) minimal or no funding gap between Phase I and Phase II. A "Commitment Appendix" and a "Product Development Plan Appendix" must accompany the Phase II proposal. The SBIR program, which was initiated in 1982, was reauthorized through fiscal year 2000 by the "Small Business Research and Development Enhancement Act of 1992" (Public Law 102-564, dated October 28, 1992). The purposesof the Act are to: (a) expand and improve the SBIR program; (b) emphasize increased private sector commercialization of technology developed through federal R&D; (c) increase small business participation in federal R&D; and (d) foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in the SBIR program. For purposes of the SBIR program, a "small business concern" is any business concern that: (a) is independently owned and operated; (b) is not dominant in the field of operation in which it is proposing; (c) has its principal place of business located in the United States; (d) is organized for profit; and (e) has, including its affiliates, no more than 500 employees. Following are the research topics identified in the PHS SBIR Contract Solicitation [PHS 99-1]: NATIONAL INSTITUTES OF HEALTH (NIH) -- NATIONAL CANCER INSTITUTE (NCI): Isolation of High Quality mRNA from Human Epithelial Tissues; Development of New Methodologies for Preservation of Human Tissue Specimens; Web Based Visualization and Analysis of DNA Micro-Array Data; Conversion of Existing cDNA Libraries into Vectors for Functional Studies; NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES (NIDDK): Assays for Identification of High Risk Individuals for the Development of Insulin Dependent Diabetes (IDDM); Transplantation of Human Islets or Beta Cells; Improved Methods for Production of Clinical Gene Therapy Vectors for Diseases of Interest to NIDDK; Acute Renal Failure; New Noninvasive Body Iron Test; Mechanical Approaches to Achieving Euglycemia; Chronic Renal Failure; Measurement of Pancreatic Beta-Cell Mass or Inflammation in the Diabetic Patient; Generation of cDNA Libraries from Hematopoietic Lineages; NATIONAL INSTITUTE ON DRUG ABUSE (NIDA): Drug Supply Services Support; Chemical Libraries for Drug Development; Analytical Techniques Program; Develop Prevention Research Dissemination; Measurement Modules for Prevention Interventions; NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES (NIEHS): Development of a Transgenic Teleost Animal Model for Assessing Mutagenesis; Commercialization of Laboratory Methods for Assessing the Genetic Responses to Chemicals; Rapid Mutational Analysis of Rodent DNA Samples; Development of Assay Systems for Determining the Formation of Mutagens by Prostaglandin H Synthase-2; Development of Applications of Human Breath Analysis for Metabolic Phenotyping of Individuals; Development and Evaluation of Transgenic Mouse/Rat Models for Problems in Environmental Toxicology and Carcinogenesis; Development of Arrayed Mouse Unigene Libraries for Use in cDNA Micro-arrays; Development of High Capacity/High Throughput Genotyping Methods for Human Polymorphisms; Development of Low Cost Gene Expression Array Technology; Development of Improved Alternative Test Methods for Ocular and Dermal Toxicity; Development of Humane Innovative Technologies for the Refinement of Toxicity Testing; NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (NHLBI): Fluorescent Indicator Dyes for Extracellular Ions; Transgenic Mice Expressing Cre-Recombinase in Specific Renal Tubule Segments; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE (NINDS): Development of Non-Pharmacological Therapy of Epilepsy; Anti-Epileptic Drug Delivery Systems and Formulations; Portable Devices for Sleep Disorder Screening/Monitoring; Non-Pharmacological Therapy of Sleep Disorders; Models for Screening Antiepileptic and Antiepileptogenic Therapy; Alertness Measures; Improved EEG/ICU/OR Interface; Improving Magnetic Resonance Imaging to Evaluate the Central Nervous System of Critically-ill Neonates; Inducible Knockout Technology; Genome Scanning; Direct Gene Transfer; NIRS Device Development for Cerebral Monitoring in the Infant and Child; Development of a MRI Head Coil for Pediatric Use; Neuroimaging in HIV Infection; CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC) -- NATIONAL CENTER FOR HIV, STD AND TB PREVENTION (NCHSTP): Development and Visual Case Analysis Software forUse by Disease Intervention Specialists During Syphilis Interviews; Production of Health Message Videos Targeting STD/HIV Risk Reduction for High Risk Adolescents; NATIONAL IMMUNIZATION PROGRAM (NIP): Assay to Detect Minimal Infectious Dose of HBsAg or Blood Surrogate; Simple Aerosol Nebulizer for Measles Vaccine Administration; Safe Injection Practice; NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID): Production of Specialized Diagnostic Products and Reagents; Develop a Portable Glovebox for Safe Management of Trapped Wild Mammals; Develop Humanized Monoclonal Antibodies for Medically Important Arboviruses; EPIDEMIOLOGY PROGRAM OFFICE (EPO): Design and Develop an Interactive, Multi-media Program on Teaching the Principles of Epidemiology, Surveillance and/or Prevention Effectiveness; PUBLIC HEALTH PRACTICE PROGRAM OFFICE (PHPPO): Geographic Information Systems and Community Health Planning; AGENCY FOR HEALTH CARE POLICY AND RESEARCH (AHCPR): Tools to Assist Children/Parents Manage Their Chronic Health Needs; Internet-Based Decision Support for Health Related Quality of Life Instruments. The PHS SBIR Contract Solicitation PHS 99-1, including proposal forms, is or soon will be available electronically through the National Institutes of Health's "Small Business Funding Opportunities" home page at http://www.nih.gov/grants/funding/sbir.htm on the World Wide Web. A limited number of hard copies of the PHS SBIR Contract Solicitation is or soon will be available from: PHS SBIR/STTR Solicitation Office, 13687 Baltimore Avenue, Laurel, MD 20707-5096, phone: (301) 206-9385, fax: (301) 206-9722, e-mail: a2y@cu.nih.gov. Posted 08/25/98 (W-SN241372). (0237)

Loren Data Corp. http://www.ld.com (SYN# 0006 19980827\A-0006.SOL)