National Cancer Institute, Research Contracts Branch, PCPSS, Executive Plaza South, Room 635, Bethesda, Md 20892

A -- EVALUATION OF CHEMOPREVENTIVE AGENTS BY IN VIVO SCREENING ASSAYS SOL MAA-N01-CN-85092-46 DUE 101598 POC Schuyler T. Eldridge, Contract Specialist, 301-435-3794 WEB: Click here to download a copy of the RFP, http://rcb.nci.nih.gov/rfp.htm. E-MAIL: Click to contact the contracting officer via e-mail, se29f@nih.gov. The National Cancer Institute, Division of Cancer Prevention, Chemoprevention Branch, wishes to award Master Agreement (MA) contracts for the above study. The required services will be defined by contracts issued during the remaining period of performance. Pursuant to the Statement of Work the Contractor shall conduct in vivo screening studies in small rodents using gavage and other routes of administration to administer the designated chemopreventive agents in animal models using any carcinogenic mechanism (that is consistent with the Evaluation Criteria), such as the administration of carcinogens, promoters, hormones, irradiation, cells or other carcinogenic agents. Agents to be tested are potentially hazardous. The animal model systems also involve the use of carcinogens. Laboratory practices shall be employed which will keep any element of risk to personnel at an absolute minimum. Where indicated, tissue and compound handling must be performed in (at least) Class I laminar flow agents. It shall be required that the animal facilities be maintained in accordance with the NIH Guide for the Care and Use of Laboratory Animals, the Animal Welfare Act as administered by the USDA, and the U.S. Government Principals for Utilization and Care of Vertebrate Animals Used for Testing Research and Training. The contractor shall have all the equipment necessary to accomplish the studies including but not limited to animal racks and caging, hazardous chemical storage cabinets and refrigerators, pathology equipment such as microscopes and microtomes and miscellaneous laboratory equipment. The laboratory shall have or have access to appropriate terminal and computer facilities and equipment for data collection and storage. Since Master Agreements are unfunded the obligation of funds shall be accomplished solely through the award of contracts. This research will be performed under cost reimbursement and/or fixed price contracts. It is estimated that four (4) to five (5) contracts will be awarded per year. Any MA awarded as a result of this solicitation will be in effect from the effective date to February 28, 2003. This solicitation will be open for the duration of the existing MA pool with due dates for receipt of proposals semi-annually, October 15, and April 15 (or the next business day) of each year. All responsible sources meeting these criteria are encouraged to submit a proposal and a sample requirement to be considered by the NCI. ALL MASTER AGREEMENT HOLDERS ALREADY IN THE EXISTING MASTER AGREEMENT POOL NEED NOT RESPOND TO THIS ANNOUNCEMENT [Current MA Holders: American Health Foundation; IIT Research Institute; Medical College of Ohio; Ohio State University Research Foundation; Southern Research Institute; SRI International; University of Alabama @ Birmingham; University of Illinois @ Chicago; University of Wisconsin]. The RFP may be accessed on or about August 1, 1998, through the Research Contracts Branch RFP page by using the following Internet address: http://rcb.nci.nih.gov/rfp.htm It is the offerors responsibility to monitor the above Internet site for the release of this solicitation and amendments, if any. POTENTIAL OFFERORS WILL BE RESPONSIBLE FOR DOWNLOADING THEIR OWN COPY OF THE SOLICITATION AND ANY AMENDMENTS. Point of contact: Mr. Schuyler T. Eldridge, Contract Specialist, NCI, RCB PCPSS; 6120 Executive Boulevard, Executive Plaza South; Suite 635, Rockville, MD 20852; Phone 301-435-3794; Fax 301-402-8579; Electronic Mail se29f@nih.gov. All requests should reference the RFP No. N01-CN-85092-46. NO COLLECT CALLS WILL BE ACCEPTED. Posted 07/15/98 (W-SN223782). (0196)

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