National Institutes of Environmental Health Sciences, Research Contracts Branch, DERT, P.O. Box 12874, Building 4401, Research Commons, 79 T.W. Alexander Drive, Research Triangle Park, NC 27709

A -- STUDIES TO EVALUATE THE ADDITIONAL TESTS OF ANTHRAQUINONE!! SOL N01-ES-25337!! DUE 072298 POC Saundra Walsh, Contract Specialist 919/541-0419!! WEB: None, None. E-MAIL: None, None. The National Institute of Environmental Health Sciences intends to negotiate with Battelle Memorial Institute, Battelle Columbus Operations, to conduct a 30-day study of anthraquinone to evaluate liver P450s; liver and kidney 9-hydroxydeoxyguanosine; cell proliferation in liver, kidney and urinary bladder, and assessment of mutagenic activity of urine in male and female treated. The contract period shall be extended to December 31, 1998. The Government anticipates an approximate level-of-effort of 2,210 hours for this additional task. Authority: 41 U.S.C. 253 (c)(1), as set forth in FAR 6.302-1 and HHSAR 306-302-1. Inherent duplication of cost to the Government and unacceptable delays in completing the project make competition unfeasible for the additional tests required to complete the study. See numbered Note 22.***** (0169)

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