National Cancer Institute, Research Contracts Branch, ESS, Executive Plaza South, Rm. 620, 6120 Executive Blvd., MSC 7224, Bethesda, MD 20892-7224

B -- NOTIFICATION OF INTENT TO AWARD NEW WORK ON A SOLE SOURCE BASIS TO THE ONGOING PROJECT ENTITLED "EARLY DETECTION OF ESOPHAGEAL CANCER." SOL N02-SC-45586 DUE 070698 POC Veronica Rozier, Contract Specialist, Phone: (301)435-3776, Fax: (301) 480-0241 E-MAIL: Veronica Rozier, vr45e@nih.gov. The National Cancer Institute, Division of Clinical Sciences, Cancer Prevention Studies Branch, intends to negotiate a modification to add new work to Contract N02-SC-45586 currently being performed by the Cancer Hospital of the Chinese Academy of Medical Sciences (CHCAMS) in the People's Republic of China. The Contractor will evaluate the ability of chemopreventive agents to cause regression of squamous dysplasias during a period of twelve months. The chemoregression study is an add-on to the ongoing Early Detection of Esophageal Cancer project, which began in 1994 under the subject contract. Over 200 patients with squamous dysplasia of the esophagus will be required for the chemoregression study. Most patients with these lesions are asymptomatic, so the subjects needed for these studies will have to be identified from an asymptomatic high-risk population. Hence, the new study will be carried out in the Linxian, region of China, a geographic area with the highest rates of esophageal cancer in the world. Authority for this action is 41 U.S.C. 253(c)(1), as set forth in FAR 6.302-1(a)(2). Refer to Numbered Note 22. All responses to this notice must be submitted in writing by mail, fax or electronic mail. Collect calls will not be accepted. (0140)

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