National Institutes of Health, Division of Research Contracts, 6100 Executive Blvd., MSC 7540, Room 6E01, Bethesda, Maryland 20892-7540

A -- HUMAN GENETIC MUTANT CELL REPOSITORY SOL NIH-GM-98-05 DUE 051898 POC Jonathan Ferguson, Contract Specialist (301) 496-4487 WEB: DRC-Request for Proposals, http://silk.nih.gov/silk/OCM/RFP.HTML. E-MAIL: Jonathan Ferguson, JF27T@NIH.GOV. The National Institutes of Health has a requirement to provide for the continued operation of a large and complex project for: 1) the collection of new cell samples, the establishment and characterization of permanent cell lines from these samples, and the maintenance and distribution of both newly established cell lines and cell lines already in the Repository's collection; 2) The preparation, storage, and distribution of purified, high-quality DNA samples from selected cell lines in the Repository; 3) The maintenance of a comprehensive computerized database providing detailed information on each cell line and DNA sample, and the provision of a Web-based electronic catalog that continues, at a minimum, to list cell lines and DNA samples and as much information about them in as easily accessible a form as is currently available; and 4) The publicizing of the Repository's collections through distribution of information by a variety of means, publication of descriptions of the collections in relevant journals, paid advertisements, and other activities. In addition to other qualifications, the successful offeror must have: 1) expertise in establishing, growing, and storing human fibroblast and lymphoblast cell lines and rodent-human somatic cell; 2) ability to characterize and distribute these cell lines; 3) ability to obtain samples from investigators and clinical documentation about the cell lines; and 4) ability to prepare, store, and distribute high quality DNA samples from cell lines. It is anticipated that a cost-reimbursement contract will be awarded for a five year period. The contract requires: 1) the maintenance of 4,000 cells per year and the acquisition of 600 cells with options for additional quantities to total 1,000 cell acquisitions per year, and 2) the preparation of approximately 200 to 800 DNA samples each year. All responsible sources may submit a proposal which shall be considered by the agency. THE SOLICITATION WILL BE AVAILABLE ELECTRONICALLY ONLY. It will be available on the following website: http://silk.nih.gov/silk/OCM/RFP.HTML will be available on or about April 2, 1998 and will close on or about May 18, 1998. OFFERORS ARE RESPONSIBLE FOR ROUTINELY CHECKING THIS WEBSITE FOR ANY POSSIBLE SOLICITATION AMENDMENTS THAT MAY BE ISSUED. NO INDIVIDUAL NOTIFICATION OF ANY AMENDMENTS WILL BE PROVIDED. (0077)

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