National Cancer Institute, Research Contracts Branch, PSAS, 6120 Executive Blvd, EPS/Room 638, Bethesda, MD 20892-7227

66 -- ELECTROPHYSIOLOGY/IMAGING STATION SOL RFQ80104-NS DUE 033098 POC Patricia Haun, Contracting Officer (301) 496-8613 The National Institutes of Health (NIH), National Cancer Institute (NCI), Laboratory of Adaptive Systems (LAS) plans to procure on a sole source basis, under authority of FAR 6.302-1, an Electrophysiology/Imaging Station for an inverted microscope from Olympus America, Inc., 2 Corporate Center Dr., Melville, NY 11747. The LAS is involved in an integral study of the molecular and cellular basis of associative memory. The project's focus is on the determination of the nature of memory traces, the discovery of molecular/cellular mechanisms related to memory formation, and Alzheimer's disease specific defects. To accomplish the study, an imaging system and related attachments are required. The imaging system shall be 100% matching and compatible to the existing Olympus inverted microscope. The system shall have the capability of synchronized (on-line) recording and monitoring of membrane electrophysiological responses and ion imaging. The imaging station shall provide full support for viewing and pointing to minute areas of objects with a pointing device (i.e., a computer mouse) and performing ion ratio analysis. The station shall allow the user to construct three dimensional structures and to transfer images directly into standard word processing, drawing, and paint programs at specified resolutions of 300 dpi, and it shall have a continuously adjustable wavelength of 300 to 800 mm and slit control. The compatibility issues with the existing microscope and the ability to perform synchronized on- line recordings of both electrophysiology and imaging make Olympus America, Inc. the only known responsible source and no other systems will satisfy the requirement. This notice of intent is not a request for competitive proposals. However, all responsible parties that believe they can meet the above requirements may submit capability statements. Information furnished shall include enough material, in sufficient detail, to all the NCI researcher to perform a proper evaluation of performance capability. All capability statements received within 15 days of the publication of this synopsis will be considered by the Government. (0075)

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