National Institute of Child Health and Human Development, Contracts Management Branch, 6100 Bldg., Suite 7A07, 6100- Executive Blvd MSC 7510, Bethesda, MD 20892-7510

A -- BRAIN AND TISSUE BANK FOR DEVELOPMENTAL DISORDERS SOL RFP NICHD-CRMC-98-08 DUE 052798 POC Mrs. Lynn Salo, 301-496-4611, FAX 301-402-3676 WEB: National Institutes of Health, http://www.nih.gov. E-MAIL: National Institutes of Health, ls59u@nih.gov. The National Institute of Child Health and Human Development (NICHD) is planning to continue the repositories of the Brain and Tissue Bank for Developmental Disorders that have been established to collect, store, and distribute specimens from infants and children with neurodevelopmental disorders from both "unaffected" (control) individuals and individuals with developmental disorders. The biopsy and/or autopsied tissues that have been included in the repositories would encompass the following disorders: diagnosed Down syndrome, other chromosome defects, mitochondrial encephalopathies, phenylketonuria and other aminoacidopathies, maternal PKU, Rett syndrome, leukodystrophies, lysosomal disorder, unexplained forms of mental retardation, sudden infant death syndrome (SIDS), dyslexia, autism, and other neurodevelopmental problems. Specific tissues that have been collected include the following; brain, spinal cord, cerebrospinal fluid, blood and serum, peripheral nerves, liver, kidney, pancreas, lungs, spleen adrenal, skeletal muscles, heart, skin, thyroid, lymph nodes, and gonads. Tissues have been obtained premortem and postmortem. These tissues have been made available to qualified investigators to support and facilitate research that leads to improved understanding of the etiology, pathology, pathogenesis, and clinical-pathological correlation of conditions that are associated with mental retardation, learning and behavioral deficits. This announcement for a brain and tissue bank is a new solicitation that will continue building and maintaining the repositories that were established in 1991 and 1993. The issuance of this RFP will be on or about March 24, 1998 and proposals are due by 4:00 P.M. (Local Time), May 27, 1998. The Institute plans to make two awards from this solicitation. Those organizations desiring a copy of the above RFP may request a copy by writing or FAXing your name and address to: Mrs. Lynn Salo, NICHD, OAM, Executive Building, Room 7A07, 6100 Executive Blvd., MSC 7510, Bethesda, Maryland 20892-7510-FAX 301-402-3676. All responsible sources may submit a proposal which will be considered. This advertisement does not commit the government to award a contract. (0072)

Loren Data Corp. http://www.ld.com (SYN# 0006 19980317\A-0006.SOL)