National Cancer Institute, Research Contracts Branch, ESS, Executive Plaza South, Rm. 620, 6120 Executive Blvd., MSC 7224, Bethesda, MD 20892-7224

B -- PROVISION OF ANIMAL FACILITIES AND PERFORMANCE OF ROUTINE EXPERIMENTS AND TESTS SOL N02-BC-81127 (Mod 1) DUE 041598 POC Barbara A. Shadrick, Contracting Officer, 301/435-3787 E-MAIL: Barbara A. Shadrick, bs92y@nih.gov. The National Cancer Institute, Division of Basic Sciences, Laboratory of Tumor Cell Biology, intends to negotiate a modification for additional effort and funds to an existing contract (N02- BC-81127) with Advanced BioScience Laboratories, Inc. This contract provides a facility for housing non-human primates and other standard laboratory animals under appropriate animal biosafety level 2 (BL2) conditions with animal biosafety level (BL-3) practices and procedures. This is a follow-up to a previous study performed in the same facility. The study contemplates handling a total of 24 non-human primates (drug treatment) every day for a period of six months. This experiment is designed as a proof of concept for a human therapeutic trial and therefore will require high standard of care for the animals. Sterile procedures and the appropriate environment are needed. In addition, it is important that the standard of care in the study be identical to the previous study performed in the same facility because this new study is an extension of the old one and reproduction is a key factor. Virological assays (NASBA) has been developed and it is essential that the same array be used in this project. Technical and veterinary assistance for all routine procedures such as inoculations and bleedings and for performance of surgical procedures and postmortem examinations are also to be provided. In addition to work associated with the care and maintenance of the animals, the contractor shall provide virological support services for experiments carried out using animals in this study. These include virological assays in appropriate BL2/BL3 laboratories to study virus load following inoculation with virus, antiviral therapy and immunization. Clinical laboratory support services are to be provided and surgical procedures and complete postmortem exams, including histological examination of tissues, are to be carried out on study animals, as required. Authority for this action is 41 USC 253(c)(1), as set forth in FAR 6.302-1(a)(2)(ii). (See Numbered Note 22). All responses to this notice must be submitted in writing by mail or fax (301-480-0241). Collect calls will not be accepted. (0061)

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