National Cancer Institute, Research Contracts Branch, PSAS, 6120 Executive Blvd, EPS/Room 638, Bethesda, MD 20892-7227

66 -- INSTRUMENTS & LABORATORY EQUIPMENT SOL RFQ-NCI-80087 DUE 031398 POC Cynthia Brown, Purchasing Agent, 301-402-4509, Patricia Haun, Contracting Officer The National Inst. of Health, National Institute of Neurologic Diseases and Stroke (NINDS) intends to contract with Biacore Inc., 200 Centennial Ave., Ste.#200, Piscataway, N.J., 08854, for the purchase of a Biacore X Processing System, w/ active temperature controls, Cat.#BR-1100-29 and X system Accessories. The Biomolecular Interaction Analysis System shall be capable of the following: 1. The instruments shall have two flow cells that are mounted simultaneously. This shall allow samples to be studied for binding to at least two different target proteins and reduces seperating expenses. 2. The instrument shall use removable sensor chips that may be directly interfaced with a mass spectrophotometer. This shall allow the direct determination of molecular weight of proteins that bind to the sensors surface. 3. The instrument shall use continuous flow of sample and buffer delivery. This shall allow for automatic washing of flow cells and permits rapid exchange for the direct determination of off rates. 4.The instrument shall include software capable of global data analysis. 5. Shall be capable of detecting low molecular weight molecules (200 molecular weight) with drift less than 0.3 resonance units/min. and noise less than 0.6 resonance units. 6. Shall include start-up reagents and a interactive CD Rom for training. 7. Shall be able to reuse the same biospecific sensor chip at least 50 times for repeated sample analysis. 8. Shall have at least 8 different sensors surfaces, including flat carboxyl, short dextran, low charge dextran, and low density dextran. 9. The contractor shall provide a Year 2000 Warranty for each hardware, software, and firmware product delivered under this contract. The contractor shall be able to accurately process the data (including, but not be limited to, calculating comparing, and sequencing) from, into, and tetween the twentieth and tewenty-first centuries and for the Year 2000 and leap year calculations. Nothing in this warranty shall be construed to limit any rights or remediesthe Government may otherwise have under this contract with respect to defects other than Year 2000 performance. This is not a request for competitive quotes. However, vendors may submit their qualification packages. The submission must be in writing and must contain sufficient detail so that a determination can be made regarding meeting the governments requirements. The submission must be received by the COB, March 13, 1998. (0051)

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