National Institutes of Health, Office of Procurement Management, 6011 Executive Blvd., Rockville, Maryland 20892-7260

66 -- SURFACE PLASMA RESONANCE DETECTOR SOL 263-98-B(BP)-0016 POC Dawn Rabunsky, Contract Specialist, 301-402-3068 eTHIS SYNOPSIS/SOLICITATION FOR COMMERCIAL ITEMS DESCRIPTION, PREPARED IN ACCORDANCE WITH FORMAT IN FAR 12.6, AS SUPPLEMENTED WITH ADDITIONAL INFORMATION INCLUDED IN THIS NOTICE. THIS ANNOUNCEMENT CONSTITUTES THE ONLY SOLICITATION, WRITTEN RESPONSES ARE BEING REQUESTED AND A WRITTEN SOLICITATION WILL NOT BE ISSUED. THE SOLICITATION NO. 263-98-B(BP)-0016, IS ISSUED AS A COMMERCIAL ITEM ACQUISITION. THE SOLICITATION/CONTRACT WILL INCLUDE ALL APPLICABLE PROVISIONS AND CLAUSES IN EFFECT THROUGH FAR FAC 97-3. INDEPENDENTLY AND NOT AS AN AGENT OF THE GOVERNMENT, THE CONTRACTOR SHALL FURNISH AND INSTALL A SURFACE PLASMA RESONANCE DETECTOR CAPABLE OF MONITORING MOLECURE BINDING PROCESS ON THE SURFACE OF A SPECIALLY PREPARED BIOSENSOR CHIP, WHILE A SOLUTION CONTAINING THE SECOND PART IS PASSED OVER THE SURFACE. THE RESPONSE MEASURED IN RESONANCE UNITS, SHALL BE A DIRECT INDICATION OF THE AMOUNT OF INTERACTING OF THE TWO PARTS THAT BIND FROM THE SOLUTION A REAL TIME BINDING CURVE PRODUCED BY THE REQURIED SURFACE PLASMA RESONANCE DETECTOR SHALL CONTAIN A VARITY OF INFORMATION. A RESPONSE SHALL SHOW BINDING, SO THE AT THE TECHNIQUE BEING USED SHALL DETECT THE PRESENCE OF BINDERS AND INDICATE WHICH SPECIFIC BINDING IS TAKING PLACE. THE SHAPE OF THE BINDING CURVE SHALL SHOW KINETIC INTERACTION. THE LEVEL OF BINGING REACHED, SHALL DEPEND ON THE AFFINITY OF THE INTERACTION. THE LEVEL OF BINDING SHALL ALSO BE AVAILABLE INDEPENDENTLY FROM THE MEASURED RATE OF BINDING AND THE AMOUNT BOUND AT A STEADY STATE SHALL BE RELATED TO THE ACTIVE CONCENTRATION OF INTERGRATION IN THE SOLUTION. A CONTRACTOR SHALL PROVIDE A SURFACE PLASMA RESONANCE DETECTOR CAPABLE OF THE FOLLOWING PERFORMANCE SPECIFICATIONS: (1) SHALL BE CAPABLE OF MONITORING BINDING IN UP TO FOUR FLOW CELLS, SEQUENTIALLY. (2) SHALL BE ABLE TO ANALYZE DATA FOR KINETICS IN A GLOBAL MANNER. (3) SHALL NOT REQUIRE USER STIRRING OF SAMPLE. (4) SHALL BE FULLY AUTOMATED, INCLUDING ADJUSTABLE PROGRAMMING STEPS OF INJECTION VOLUMES OF 5 TO 750 MICRO LITERS AND RATES OF 1 TO 100 MICRO LITERS/MINUTE AND DATA ANALYSIS. (5) SHALL BE ABLE TO RUN UP TO 192 SAMPLES DIRECTLY FROM MICROTITER PLATES OR SEALED VIALS. (6) BECAUSE GLASS CAN ABSORB OR DENATURE PROTEINS, THE FLOW CELL SHALL BE MADE OF ANOTHER MATERIAL. (7) THE DRIFT SHALL BE LESS THAN 0.3 RESONANCE UNITS/MIN AND NOISE SHALL BE LESS THAN 0.6 RESONANCE UNITS. (8) SHALL BE ABLE TO REUSE THE SAME BIOSPECIFIC SENSOR CHIP FROM 50 TO 100 TIMES FOR REPEATED SAMPLE ANALYSIS. DESCRIPTIVE LITERATURE MUST BE INCLUDED WITH THE OFFEROR=S BID. THE DESIRED DELIVERY SCHEDULE IS MARCH 4, 1998. THE REQUIRED DELIVERY SCHEDULE IS APRIL 6, 1998. QUANTITY. -- ONE CLOSING DATE: ALL BIDS MUST BE RECEIVED BY 2:00 PM (LOCAL TIME), FEBRUARY 25, 1998. (0037)

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