DHHS, PHS, CDC, NIOSH, ALOSH, 1095 Willowdale Rd., Morgantown, WV 26505-2888

88 -- REDERIVATION OF PATHOGEN FREE MICE SOL RP98-002 DUE 112097 POC Brenda Goodwin, 304/285-5882/Contracting Officer, Rex S. Wolfe, 304/285-5883 THIS IS A COMBINED SYNOPSIS/SOLICITATION FOR COMMERCIAL ITEMS PREPARED IN ACCORDANCE WITH THE FORMAT IN SUBPART 12.6, AS SUPPLEMENTED WITH ADDITIONAL INFORMATION INCLUDED IN THIS NOTICE. THIS ANNOUNCEMENT CONSTITUTES THE ONLY SOLICITATION; BIDS ARE BEING REQUESTED AND A WRITTEN SOLICITATION WILL NOT BE ISSUED. This solicitation is issued as Request for Proposal No. RP98-002. This procurement is being issued unrestricted. The Standard Industrial Classification is 8734 with a size standard of $5 million in annual receipts. This solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 90-46. Furnish to the National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Road, Morgantown, WV one (1) job -- Embryo or caesarian rederivation of 14 strains of pathogen free mice. SPECIFICATIONS: The contractor will embryo or caesarian rederive 14 strains of mice at an AAALAC approved animal facility so that they are free of the specific pathogens detailed below. Freedom from the specific pathogens shall be confirmed for each strain by established serologic techniques (ELISA and/or IFA for viruses), microbiologic techniques (for most bacterial pathogens), and PCR (for Helicobacter hepaticus and Helicobacter spp.). The mice shall then be shipped in filtered containers so as to minimize the potential contamination during shipment and so as to arrive alive and healthy within 48 hours of shipment at the animal facility of the Health Effects Laboratory Division of NIOSH in Morgantown, WV. At least 3 breeding pairs shall be available per mouse strain. The strains are SENCAR, BJ.D2N (Ah-d), B6J.AKR (Ah-d), B6J (Ah-d).C3H (Ah-b2/Ah-b2), B6J(Ah-d).MOLF(Ah-b3/Ah- b3), D2J.B6J(Ah-b1), D2J.C3H(Ah-b2), C3H.D2(Ah-d), C3H.B6 (Ah-b1), D2J.HRS (hr/+), SENCAR.Skh(hr/+), B6.129 (Ah-/-), B6.SV40 and Skh/hr-1. The foundation mice to be provided by NIOSH are currently positive for EDIM, Helicobacter hepaticus, Helicobacter bilis, Helicobacter spp, and/or Pasturella pneumotropica. The rederived mice shall be seronegative for the following murine pathogens: Sendai virus, pneumonia virus of mice, mouse hepatitis virus, minute virus of mice, GD-7, reovirus 3, Mycoplasma pulmonis, lymphocytic choriomeningitis virus, ectromelia, K virus, polyoma virus, mouse adenovirus, epidemic diarrhea of infant mice, mouse cytomegalovirus, Hantaan, Encephalitozoon cuniculi, MTLV, cilia-associated respiratory bacilli, and MPV. Cecal bacterial cultures will be negative for Salmonella sp. Colon cultures shall be negative for Citrobacter freundii 4280, other Citrobacter freundii, Klebsiella pneumoniae, Klebsiella oxytoca. Respiratory tract cultures shall be negative for Corynebacterium kutscheri, Mycoplasma pulmonis, Pasteurella multocida, Pasturella pneumotropica, Pasturella sp., Streptococcus pneumoniae, Beta hemolytic Streptococci Group B, Beta hemolytic Stretococci Group G, and Beta Steptococci sp. The rederived mice shall be negative for ectoparasites and endoparasites by direct examination and will have no evidence of Helminth ova on fecal flotation. The rederived mice shall be negative for enteric protozoa by a protozoa screen. The rederived mice shall be negative by polymerase chain reaction for Helicobacter bilis, Helicobacter hepaticus, and Helicobacter spp. The rederived mice shall show no evidence of infectious disease by routine histopathologic examination of the heart, lung, liver, spleen, kidneys, or any tissue with gross lesions. The Government desires delivery in accordance with the following schedule: Some rederived mice shall be provided to NIOSH within three (3) months of NIOSH providing the foundation mice; and all mice shall be rederived within six (6) months of NIOSH providing the foundation mice. Offerors shall provide a written proposal which discusses their quality control for testing and confirming rodents are free of the specified pathogens. Evaluation Factors: To assure the quality of the rederivation, the successful offeror must provide evidence in their offer that their facility has operated an AAALAC approved commercial animal facility for at least 10 years; has on-site laboratory animal diagnostic capabilities; and has commercially rederived laboratory mice for at least 5 years. Offers will be evaluated for quality control and technical compliance with the stated specification. In the evaluation process, technical proposals and cost or price are of approximately equal importance. OFFERS SHALL BE PROPOSED BASED ON F.O.B. DESTINATION (MORGANTOWN, WEST VIRGINIA). Information provided with your offer must demonstrate your ability to meet the specification or your offer may be rejected. The following FAR provisions apply to this solicitation: FAR 52.212-1, Instructions to Offerors -- Commercial Items; 52.212-4, Contract Terms and Conditions -- Commercial Items and 52.212-5 Contract Terms and Conditions Required to Implement Statutes or Executive Orders -- Commercial Items. Additionally, the following FAR clauses cited in Clause 52.212-5 are also applicable tothis acquisition as follows: FAR 52.222-3 "Convict Labor (E.O. 11755)", 52.233-3 "Protest After Award (31 U.,S.C. 3553 and 40 U.S.C. 759)", 52.203-6 "Restrictions on Subcontractor Sales to the Government, With Alternate I"; 52.203-10 "Price or Fee Adjustment for Illegal or Improper Activity", 52.219-8 "Utilization of Small Business Concerns and Small Disadvantaged Concerns; 52.222.26 "Equal Opportunity"; 52.222-35 "Affirmative Action for Special Disabled and Vietnam Era Veterans"; 52.222-36 "Affirmative Action for Handicapped Workers"; 52.222-37 "Employment Reports on Special Disabled Veterans and Veterans of Vietnam Era"; 52.225-3 "Buy American Act -- Supplies"; 52.225-18 "European Community Sanctions for End Products." No other solicitation documents will be issued. Offers are due November 20, 3:00 p.m. local prevailing time. Submit the following to DHHS, PHS, CDC, NIOSH, ALOSH, Attn: Brenda Goodwin, 1095 Willowdale Road, Morgantown, WV 26505: (1) original and three copies of a completed SF 1449, signed by an individual authorized to bind the organization; (2) Schedule of Offered Supplies/Services containing pricing and description of Contract Line Items (CLINs) required to meet specification; (3) completed Representations and Certifications -- Commercial Items, FAR 52.212-3; (4) for evaluation purposes: a proposal demonstrating compliance with all specifications; and (5) acknowledgment of solicitation amendments, if any. Facsimile Bids are notauthorized. Offers that fail to furnish the required information, or reject the terms and conditions of the solicitation may be excluded from consideration. Award of a one firm fixed-price contract is anticipated. Forms required for submission of an offer can be obtained from Brenda Goodwin at (304)285-5882 or by fax at (304) 285-6083. All responsible sources may submit a response, which shall be considered by the Agency. (0304)

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