National Cancer Institute, Research Contracts Branch, PSCS, 6120 Executive Blvd, Eps/room 638, Bethesda, MD 20892-7227

66 -- SPECTRAL BIO-IMAGING SYSTEM FOR SKY SOL RFQ70127-NS DUE 081297 POC Patricia Haun, Contracting Officer 301-496-8613 The National Cancer Institute (NCI) proposes to procure a High Sensitivity "Turnkey" Spectral Bio-Imaging System for SKY (Spectral Karyotyping) from Applied Spectral Imaging (ASI) Inc., 2120 Las Palmas Drive, Carlsbad, CA 92009. The NCI Medicine Branch plans to use this system in a collaborative research project with the National Human Genome Research Institute (NHGRI), who's investigator is one of the inventors of the SKY process and has established a distinct technology for this simultaneous display of all human chromosome in different colors. It is believed that methodology of cytogenetic analysis is the most refined currently achievable. The ASI Spectra Cube system has been specifically designed for the kind of high resolution spectral karyotyping required for this collaborative project and its effectiveness and versatility has been documented in numerous publications from one of NHGRI's laboratories. It is believed that the ASI Spectral Imaging System is the only system which can meet the needs ofthe Government. The system offers the most sophisticated, proprietary Spectra Cube technology for applications requireing high sensitivity and dynamic range, the ability to adjust fluorescent labels and imaging specifications to allow for high throughout cloning of multiple aberrations simultaneously, acousto-optical tunable filters, variable spectral resolution, broad spectral bandwidth, and independence from polarization. This system is anexact duplicate of the system in NHGRI and compatiblity with that existing technology is imperative as the ability to use both systems to analyze samples without having to make adjustment or attempt to correct any discontinuity between systems. This notice of intent is not a request for competitive proposals, however, if any interested party who believes they have a system which can meet the above requirements, may submit a statementof capabilities and a detailed description of the machines capabilities. Information furnished shall be iin sufficient detail, to perform a proper evaluation of their ability to meet the Government's requirements. Capability statements must be received within 20 days of the publicatioon of this notice. See Note 22. (0205)

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