Centers for Disease Control and Prevention (CDC), Procurement & Grants Office, Program Acquisition Branch, 255 East Paces Ferry Rd, NE, Rm 500, Atlanta, GA 30305

B -- CHARACTERIZE THE NATURAL HISTORY OF HUMAN PAPILLOMAVIRUS (HPV) INFECTION AND HPV-ASSOCIATED DISEASE IN WOMEN PREVIOUSLY DIAGNOSED WITH CERVICAL INTRACPITHELIAL NOEPLASIA SOL 200-97-0634(P) DUE 081597 POC Dale F. DeFilipps, Contract Specialist, (404) 842-6785 The Centers for Disease Control and Prevention (CDC) contemplates awarding a Sole Source contract to the Baylor College of Medicine to characterize the natural history of Human Papillomavirus (HPV) Infection and HPV-Associated Disease in Women Previously Diagnosed with Cervical Intracpithelial Noeplasia (CIN), and to characterize the magnitude and duration of the serologic response to various HPV proteins in women with HPV-associated CIN I. The contractor shall provide a database of clinical and HPV results; clinical specimens; sera for testing for response to HPV proteins; and collaborative data as agreed upon with CDC staff. The anticipated performance period is 12 months. Options may be exercised for two additional years. The proposed contract is a follow-on to contract no. 200-92-0537 with Baylor College of Medicine, and, under that contract, two-years of follow-up data and clinical specimens have already been collected on a specific cohort of women diagnosed with CIN 1. Data from other cohorts from another contractor could not be combined with the existing follow-up data. Awarding a contract to another offeror and changing cohorts at this point would cause significant disruption in the HPV Program and significantly inhibit VEHB from completing an important program goal; the Utility of HPV Screening in Cervical Disease. The specific cohort of women who provided the clinical data and specimens are not available to anyone other than Baylor College of Medicine. Hence, a Sole Source contract to Baylor is contemplated. All responsible sources may be submit a response which will be considered by the agency. See Note 22. (0196)

Loren Data Corp. http://www.ld.com (SYN# 0017 19970717\B-0006.SOL)