Office of Naval Research, 800 North Quincy St., Arlington, VA 22217-5660

A -- BASIC AND APPLIED BIOMIEDICAL RESEARCH IN COMBAT CASUALITY CARE SOL BAA 97-022 DUE 071597 POC Dr. C. Oliver, ONR 335 (703)696-4053 ONR BAA-97-022 The Office of Naval Research and the Naval Medical Research and Development Command are jointly soliciting preproposals directed at basic and applied biomedical research focusing on Navy-relevant aspects of combat casualty care, particularly hemorrhagic shock and blood products. This notice constitutes a Broad Agency Announcement (BAA) as contemplated in FAR6.102(d)(2). The following aspects of hemorrhagic shock research and development are of interest: (1) mechanisms and treatment of hypoxic injury at the cellular and molecular level (POC: Dr. C. Oliver (703) 696-4053), (2) neural induction and neuro/endocrine regulation of cytokines and other soluble mediators involved in hemorrhagic shock (POC: Dr. J. Majde (703) 696-4055), (3) novel therapeutic interventions for severe hemorrhage and shock (POC: Drs. Oliver or Majde), (4) methods for casualty stabilization and life sustainment following massive hemorrhage (POC: CDR L. Yaffe (301) 295-1825), and (5) design, testing and evaluation of supportive and therapeutic resuscitation fluids (POC: Drs. Oliver or Majde). The following aspects of blood product research and development are also of interest: (1) methods for the extension of liquid storage of red cells and platelets (POC: CDR L. Yaffe), (2) cryopreservation of blood products not requiring post-thaw cryoprotectant washout (POC: CDR L. Yaffe), (3) bone marrow transplantation for military contingencies (POC Dr. Oliver), and (4) impact of blood substitutes at the molecular, cellular & organ system levels in treatment of hemorrhagic shock (POC Drs. Oliver or Majde or CDR Yaffe). It is not the intent of this solicitation to establish new facilities, rather, institutions having demonstrated research capability and the necessary facilities are invited to submit five copies of a preproposal not exceeding three pages of text that describes: (a) the research objective, (b) the research approach, ( c) related work by the proposer, (d) anticipated contributions to the Navy program, and (e) and estimate of overall costs (including indirect) for a three year effort. A curriculum vitae of the principal investigator(s) should be appended together with any supporting information, such as reprints or preprints, that will assist in the evaluation of the preproposal. Preproposals whose main objectives are to conduct analyses, literature reviews, or program evaluations are not encouraged. Preproposals and proposal submissions will be evaluated on the following criteria: (1) scientific, technical, and socio-economic merits of the research (socio-economic -- not applicable to grant applications), (2) qualifications and experience of the principal investigator(s), (3) relevance of the proposed research to agency program priorities, (4) realism of proposed costs, and availability of funds. There will be no formal requests for proposals or other formal solicitations regarding this announcement. For awards made as contracts, evaluation of the socio-economic merits of the proposal shall include the extent of commitment in providing meaningful subcontracting opportunities for small business, small disadvantaged business, woman-owned small business concerns, historically black colleges, universities and minority institutions. The standard industrial classification code is 8731 with the small business standard of 500 employees. In addition, contract proposals that exceed 500 employees submitted by all but small businesses, must be accompanied by a Small, Small Disadvantaged and Women-Owned Small Business Subcontracting Plan in accordance with FAR 52.219-9. All formal proposals for competitive review will be requested based on those submissions judged most likely to meet program objectives. Proposal deadline date and format instruction will be provided at that time. The initial deadline for preproposals will be 15 July 1997. Preproposals may be submitted after for consideration in the next funding cycle. Preproposals (5 complete copies) should be sent to either Dr. Harold Guard, Acting Director, Biomedical Science and Technology Division, Office of Naval Research, 800 N. Quincy Street, Arlington, VA 22217-5660, (703) 696-4986 or to CDR Lyn Yaffe, Director, Research and Development, Naval Medical Research and Development Command, National Naval Medical Center, Bethesda, MD 20889, (3 01) 295-1825. Questions regarding proposal business issues and legal matters relating to this BAA should be directed to Brian Glance, Code 252, Office of Naval Research, Ballston Tower One, 800 North Quincy St., Arlington, VA 22217-5660, Phone (703) 696-2596. (0156)

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