National Institute of Mental Health, 5600 Fishers Ln., Rm. 9C-15,, Rockville, MD 20857-8030

A -- RESEARCH UNITS ON PEDIATRIC PSYCHOPHARMACOLOGY: AUTISM AND OTHER PERVASIVE DISORDERS SOL NIMH-97-CR-0001 DUE 052797 POC Patricia L. Gibbons,(301)443-2696 In September 1996, the National Institute of Mental Health (NIMH) ) funded Research Units on Pediatric Psychopharmacology (RUPPs), that are currently active in conducting research in children and adolescents with anxiety disorders. The NIMH plans to augment these sites with RUPPs which will focus on the much understudied area of autism and other pervasive developmental disorders. The purpose of this requirement, "Research Units on Pediatric Psychopharmacology: Autism and Other Pervasive Developmental Disorders," is to support the establishment of qualified clinical research units that, by building on existing research resources at the host institution and combining the necessary expertise in clinical pharmacology and child psychiatry, can become national resources where the safety and efficacy of psychotropic medications for patients suffering from autism, other pervasive developme ntal disorders, and other psychiatric disorders of childhood can be conducted in a prompt and cost effective manner. Theseunits will work as a network of research sites and conduct high priority clinical studies in various pediatric ages, addressing various aspects of pediatric psychopharmacology, including (but not limited to): dose ranges, dosing regimen, pharmacokinetics, general safety profile, efficacy and effectiveness, and long-term effects on cognition, behavior and development. The successful off eror will need to exhibit the availability of staff, facilities, and institutional support necessary to conduct clinical trials on children, using FDA approved psychotropic medications. The offeror will also need to exhibit the ability to obtain funding support from non-Federal sources to perform clinical trials of this type. NIMH proposes to issue an unrestrictive competitive solicitation for this requirement and anticipates the award of a cost reimbursement contract for a period of three years. Request for Proposal (RFP) No. NIMH-97-CR-0001 will be available electronically on or about May 27, 1997, with proposals due on or about July 14, 1997. The RFP may be accessed through either the NIH Home Page, the NIH Gopher or the NIMH Home Page by using the following electronic addresses and instructions: 1. NIH Home Page (via the World Wide Web): Access the NIH Home Page by using http://www.nih.gov. Once you are at the NIH Home Page, select "Grants and Contracts," then select "NIH Gopher directory," item listed under the "Contracts Page" Section. The Uniform Resource Locator (URL) for this gopher director is gopher://gopher.nih.gov:70/11/res/rd-rfp 2. To access the NIH Gopher: Point your gopher client to GOPHER.NIH.GOV PORT 70 (you should now be in the NIH Gopher). Select "Grants and Research Information," then select "R&D Requests for Proposals (RFP)." 3. NIMH Home Page: Access the NIMH Home page by using http://www.nimh.nih.gov. Once you are there, select "Grants, Contracts & Committees," item listed under "NIMH Request for Proposals (RFP)." Please note that the RFP for this procurement has been revised to include only the Statement of Work, Deliverable and Reporting Requirements, the Technical Evaluation Criteria, and proposal preparation instructions. All information required for the submission of an offer will be contained in the electronic RFP package. Following proposal submission and the initial review process, offerors comprising the competitive range will be requested to provide additional documentation to the Contracting Officer. Al l responsible sources may submit a proposal that will be considered by the NIMH. This advertisement does not commit the Government to award a contract. Point of Contact: Patricia Gibbons, Contracting Officer, Contract Management Branch, National Institute of Mental Health, National Institutes of Health, 5600 Fishers Ln., Rm. 9C-15, Rockville, MD 20857-8030. Electronic mail address: pgibbons@nih.gov, Telephone: (301)443-2696, FAX: (301) 443-0143. No collect calls will be accepted. (0133)

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