National Institute of Environmental Health Sciences, Contracts and Procurement Management Branch, OM, 79 T.W. Alexander Drive, 4401 Building, P.O. Box 12874, Research Triangle Park, NC 27709

A -- SUPPORT FOR THE PREPARATION OF THE BIENNIAL REPORT ON CARCINOGENS (BRC) SOL NIH-ES-97-29 DUE 062397 POC Contact Howard Hill, Contract Specialist, (919) 541-4971, Contact t Thomas Hardee, Contracting Officer, (919) 541-0429 The National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), is soliciting proposals from offerors that have these capabilities and facilities to perform the following: The objective of this contract is to procure assistance in preparing the Biennial Report on Carcinogens (BRC). This includes the use of detailed literature searches to develop pertinent information and data on agents, substances, mixtures or exposure circumstances being considered by the NTP for listing in or delisting from the BRC. This information is needed in the application of the criteria for listing and delisting agents, substances, mixtures or exposure circumstances in the BRC and includes, but is not limited to human epidemiology studies, animal bioassays, dose response, route of exposure, chemical structure, metabolism, pharmacokinetics, sensitive sub populations, genetic effects, or other data relating to mechanism of action or factors that may be unique to a given substance. The contractor shall assist the Government in identifying, gathering, collating, and summarizing existing data, estimates, and information on the carcinogenicity of a substance being evaluated for the BRC as well as the mechanism of action; the nature of exposure, its level, the number of persons exposed, and its regulatory status. The data bits to go into this effort may be provided by the Project Officer but in most cases will have to be obtained from appropriate data sources by the Contractor. The Contractor shall provide support for the review of approximately 25 agents, substances, mixtures or exposure circumstances per year for listing in or delisting from the BRC. In addition the Contractor shall be expected to update the information on the agents, substances, mixtures or exposure circumstances contained in the immediately proceeding BRC. The Government estimates that the project will require approximately 1.4 professional person years, 3.9 technical person years, 1.4 clerical person years and 0.5 computer support person years per contract year. The estimated period of performance is 3 years, plus two (1-year) optional years. The contract will be a level-of-effort, term form cost reimbursement type contract. Requests must reference RFP No. NIH-ES-97-29 and must be directed to the office listed above. The proposed contract is 100 percent 8(a) set aside. All responsible small disadvantaged business concerns may submit a proposal which shall be considered by the Agency. See Note 4. (0112)

Loren Data Corp. http://www.ld.com (SYN# 0005 19970424\A-0005.SOL)