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COMMERCE BUSINESS DAILY ISSUE OF JANUARY 23,1997 PSA#1767National Institute of Environmental Health Sciences, Contracts &
Procurement Management Office, OM, P. O. Box 12874, Research Triangle
Park, NC 27709 A -- GENETIC TOXICITY TESTING IN RODENTS SOL NIH-ES-97-26 DUE 020397
POC Saundra J. Walsh, Contract Specialist 919/541-0419, Elizabeth B.
Ford, Contracting Officer 919/541-0415 This requirement is to provide
the Government with the capacity to test approximately 15 chemicals per
year for five years for somatic cell genetic effects in rats and/or
mice. All tests will not be performed on all chemicals. Tests to be
performed will include ABS in bone marrow, ABS in peripheral
lymphocytes, MN in bone marrow, MN in peripheral erythrocytes from
sub-chronic studies (mice only), MN in peripheral lymphocytes, MN in
other tissues (e.g. lung, spleen), centromeric probe analysis of MN,
Single-cell gel electrophoresis assays of various tissues, measurement
of mutations in liver of transgenic animals, and measurement of
mutations in other tissues of transgenic animals. All work shall be
performed in a manner compatible with the NTP Health and Safety Minimum
Requirements. All laboratory records shall be kept in accordance with
FDA Good Laboratory Practice regulations (Federal Register, Friday,
September 4, 1987, pp. 33768-33782 (21 CFR Section 58)). All animal
care and handling procedures shall be in accord with the appropriate
sections of the NIEHS "Specifications for the conduct of studies to
evaluate the toxic and carcinogenic potential of chemical, biological
and physical agents in laboratory animals for the National Toxicology
Program (NTP)." Two contract awards are anticipated for this
requirement. Each contract award is estimated to be a base contract of
three years, with two one-year options for continued support. The
contract shall not exceed five years. In the initial contract award the
first years effort may be to conduct the genetic toxicity tests on up
to fifteen chemicals, or, in the event that the contract is awarded to
a firm without prior demonstrated experience with the NTP, year 1 will
consist of a two phased effort. The project has been divided into four
tasks, each representing a different test system, induction of ABS and
MN in bone marrow and other tissues (Task 1), testing for the presence
of centromeres in MN (Task 2), induction of DNA damage as measured by
the single-cell gel assay (Task 3), and induction of gene mutations in
transgenic rodents (Task 4). It is recognized that not all contractors
may have the expertise in all four task. All offerors must respond to
Task 1, the measurement of ABS and MN in rodents. Offerors are not
required to respond to Tasks 2, 3, and 4, although they are expected to
have expertise in, and respond to, a least one of these additional
tasks. The contracts to be awarded will be complementary, in that,
together, the contractors shall have expertise in all four tasks. Both
contract awards will be level-of-effort, term-form cost reimbursement
type contracts. It is estimated the project will require 0.5
professional person-years and 1.5 technical person-years per contract
year. The principal investigator and professional staff should have
training and experience in the areas of cytogenetics and chemical
mutagen testing using the test procedures described in the statement of
work. It is expected that the contracts will be awarded by September
30, 1997, with each contract to expire by August 31, 2002 (if all
options are exercised by the Government). The expected release date of
the RFP is January 31, 1997. Interested organizations who request a
hard copy of the solicitation should request either a streamlined or
full RFP package. If no selection is made, a streamlined version of the
RFP will be provided. The streamlined version includes only the
Statement of Work, deliverable and reporting requirements, special
requirements and mandatory qualifications, if any, and technical
evaluation criteria. On the release date, a copy of the streamlined
version of the solicitation will be available, on the Internet at:
http://www.niehs.nih.gov/omcpmb/external/. Those individuals who wish
to access the on-line version should follow the instructions provided
in the on-line solicitation package. After examination of these
documents, any organization interested in responding to this RFP must
request the entire RFP in writing or by telephone (919) 541-0419 or by
FAX request (919) 541-2712. This requirement is restricted to 100%
Small Business competition. All responsible sources may submit a
proposal which shall be considered by the agency. The SIC Code is 8731.
(0017) Loren Data Corp. http://www.ld.com (SYN# 0005 19970123\A-0005.SOL)
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