National Institute of Environmental Health Sciences, Contracts and Procurement Management Branch, OM, 79 T.W. Alexander Drive, 4401 Building, P. O. Box 12874, Research Triangle Park, NC 27709

A -- MOLECULAR ANALYSIS OF LACI MUTATIONS DERIVED IN THE BIG BLUE TRANSGENIC MOUSE POC Contact Vondia C. Malone, Contract Specialist, (919) 541-0428; Phillip D. Jones, Contracting Officer, (919) 541-0426 The National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), intends to negotiate with the University of Victoria, Center for Environmental Health, Victoria, B.C., Canada as a sole source for a three year extension to existing contract number N01-ES-35365, under the authority of 41 USC 253(c)(1), as set forth on FAR 6.302-1. The University of Victoria will characterize by DNA sequence analysis laci mutants derived in Big Blue mice in a series of validation experiments. Each and every mutant from tissues and animals in these validations studies have been carefully documented and saved. These have been stored and duplicate samples have been transferred to the Center for Environmental Health at the University of Victoria for storage and further analysis. The University of Victoria is the only source that has been provided with the experimental data and is the only source entitled to use these data in further research. Any other source would, at this point, have to repeat the validation studies. Inherent duplication of costs to the Government, restricted access to the data, and unacceptable delays in completing the study make competition unfeasible. See Numbered Note 22. (0354)

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