Contracts Management Branch, National Institute of Child Health and Human Development, NIH, Executive Building, Suite 7A07, 6100 Executive Blvd MSC 7510, Bethesda, Maryland 20892-7510

A -- PROSPECTIVE PREGNANCY STUDIES SOL NICHD-DESPR-SS-00 POC Contact Mrs. Lynn Salo, 301/496-4611 The National Institute of Child Health and Human Development (NICHD) is seeking a source of data and biological specimens for studies of birth defects, preterm birth and other adverse pregnancy outcomes. The NICHD does not plan to provide funding to set up such a study but rather will provide monetary support for a study that has been done, is being done or soon will be done. Funding will be provided so that data on topics of interest to NICHD can be collected and analyzed. NICHD wants data collected prospectively (during the pregnancy of interest) including the following: 1) Blood samples - including serum or plasma and material suitable for genetic studies collected during the pregnancy. 2) High quality medical data on the pregnant subjects collected during the pregnancy by individual interviews or self-administered questionnaires. At a minimum these data should include maternal socioeconomic data, medical history, obstetrical history, and pertinent exposure history (drugs, toxins, infections). 3) Follow-up information on pregnancy outcomes including late complications of pregnancy/delivery, presence of birth defects in offspring, neonatal problems, birth weight and other anthropometric measures. 4) Ability to re-contact subjects (mothers and offspring) to obtain additional medical information. This should include at lease minimal ability to link records and the ability to locate a large proportion of subjects, for examples, by identification numbers. 5) The sample should be population or geographically based with evidence of a geographically clearly defined cohort and the ability to identify virtually all pregnancies with that area. 6) A minimum of 50,000 pregnancies over a period of 3 years should be in the study. 7) The option of following children until they reach school age should be available. That is to say, there should be an efficient method of tracking the children. The purpose of this synopsis is to determine whether there are sources capable of meeting the criteria as described above. Capability statements should be submitted within 45 days of publication of this synopsis and include details specifying how they would carry-out the work. Capability statements should be submitted to Mrs. Lynn Salo, NIH, NICHD, CMB, Executive Building, Room 7A07, 6100 Executive Blvd., MSC 7510, Bethesda, Maryland 20892-7510 OR if by OVERNIGHT mail 6100 Executive Blvd., Rockville, Maryland 20852. (See Numbered Note 22)(0318)

Loren Data Corp. http://www.ld.com (SYN# 0010 19961114\A-0010.SOL)