National Cancer Institute, Research Contracts Branch, TCS 6120 Executive Blvd, EPS/RM 603Bethesda, MD 20892-7220

A -- PATHOLOGY & VETERINARY SUPPORT SERVICES SOL NCI-CM-77027-30 DUE 112296 POC Elsa B Carlton, Contract Specialist, 301-496-8620 or Therese M Dick, Contracting Officer, 301-496-8620. The National Cancer Institute (NCI), Division of Cancer Treatment, Diagnosis and Centers (DCTDC), Developmental Therapeutics Program (DTP) anticipates the award of one (1), cost-reimbursement contract, for a 5 year period, beginning on or about July 30, 1997. As a minimum requirement, the contractors must comply with the FDA's current Good Laboratory Practice Regulations (GLPs). The proposed awarded contract will be administrated on a work assignment managed basis. Work assignments will be issued under the proposed, level of effort, contract resulting from this solicitation. DTP is seeking organizations to perform a variety of pathology and veterinary services to support the DTP preclinical toxicology and pharmacology program for anticancer and anti-AIDS drug development. The organization should have the facilities and staff to carry out the requested efforts and the management expertise to respond to the diverse and changing needs of this project. Specifically, the work assignments to be issued will involve the following: operation of a repository to hold the pathology materials and raw data generated in past and future toxicology studies; storage of data on optical medium; performance of an independent verification (peer review) of the pathological findings by the study pathologist especially with respect to individual diagnoses, drug-relatedness, nomenclature and slide quality; provide a pathology support program to prepare blocks and slides and conduct histopathological evaluation of tissues; perform the site visits to conduct necropsies, slide preparation or to assist the Project Officer in project evaluation. This includes providing expertise in special techniques to assess cardiotoxicity, neurotoxicity, nephrotoxicity, etc.; storage, maintenance and shipment of Government infusion equipment to other DTP contractors; development and implementation of new surgical or other procedures for drug administration or sampling; instruction in these procedures; or performance of these procedures in actual animal studies; conduct site visits to the DTP toxicology contractor laboratories to evaluate pathology laboratories, animal care programs or to investigate pathology or animal care problems; and to support the Toxicology and Pharmacology Branch toxicology efforts required through the preparation of study protocols, study monitoring and report evaluation. The Principal Investigator should be a board certified veterinary pathologist or veterinarian with at least three years experience with similar programs. This is recompetition of a contract performing these activities. The Request for Proposal will be available on or about October 3, 1996. No collect calls will be accepted. (0261)

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