National Institute of Child Health and Human Development, Contracts Management Branch, Executive Building, Suite 7A07, 6100 Executive Blvd., MSC 7510, Bethesda, MD 20892-7510

A -- COL-1492, ADVANTAGE 24 IN THE PREVENTION OF TRANSMISSION OF STDS AND HIV Sol NICHD-CDB-96-11, contact Paul J. Duska, Contracting Officer, (301) 496-4611. The Contraceptive Development Branch of the Center for Population Research, National Institute of Child Health and Human Development (NICHD), intends to negotiate with the World Health Organization (WHO) to participate in a multi-center controlled clinical trial for evaluation of a spermicidal product for protection against pregnancy and sexual transmission of HIV to women. This work is under way in developing countries and will be augmented by the addition of three new sites. WHO protocols are in place among developing countries with seroincidence of HIV between 4% and 20% per year and at sites capable of providing 200 woman-years of use during a two-year period. The determination to use other-than full and open competition was made in accordance with 41 USC 253 (c)(1), FAR 6.302-1. See Note 22. (183)

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