MULTIVARIATE CLASSIFICATION OF INFRARED SPECTRA OF CELL AND TISSUE SAMPLES Your company manufacturers medical diagnostic devices. You know that the cancer diagnostic imaging and therapeutic equipment market revenue forecast into the year 2000, is projected to be a $2 billion dollar market, with a compound annual growth rate of close to 14%. Sandia National Laboratories has a patent pending on the ``Multivariate classification of infrared spectra of cell and tissue samples.'' We have developed a device and method for classifying cell and tissue samples as normal or abnormal using infrared spectroscopy coupled with a multivariate classification software analysis tool. We believe this tool can help your company capture a portion of this future huge market segment. Currently, Sandia is looking for companies who would be interested in manufacturing the technology, as well as those who would be interested in developing applications for the technology. The ``Multivariate classification of...cell and tissue samples'' is available for commercial licensing. Much development has already happened on the technology. However, Sandia needs commercial sector partners to take the technology to the next stage-a new medical device that enhances diagnostic benefits and revenues as well. The following is a summary of the research and development that has already been achieved. The initial development has been with mid-infrared spectra on cytology and histopathology samples with canine lymphoma as the test model. Classification of the cells as normal, hyperplastic and neoplastic (malignant) has been achieved with 100% accuracy by coupling infrared spectroscopy at multiple wavelengths with multivariate classification methods such as partial least squares, principal component regression, and linear discriminate analysis. Extensions of neoplastic multivariate classification methods are claimed for both in-vitro and in-vivo cell and tissue classifications. These methods might also be employed during surgical biopsies to achieve rapid classifications of tissue and cells during the surgical procedure. Coupling fiber optic probes with mid-or near-infrared spectral multivariate classifications might be used for in-vivo detection of cancers on the surfaces of tissues (e.g. detection of skin, cervical, uterine, colorectal, mouth, throat, esophageal, or stomach cancers). Near-infrared classification of tissues within nearly 1 cm of the surface may also be possible. If you are interested in learning more about the ``Multivariate classification of.....cell and tissues samples'' please contact Joanne by June 7, 1996. Joanne Trujillo, Technology Partnerships & Commercialization, Sandia National Laboratories, P.O. Box 5800-MS 1380, Albuquerque, NM 87185, FAX: 505/843-4175. Potential Sandia partners will be evaluated by their commercialization plan and an evaluation whether the company has the ability to commercialize this technology successfully.

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