National Library of Medicine, Office of Acquisitions Management, Building 38A, Room B1N17, 8600 Rockville Pike, Bethesda, MD 20894

A -- CONSTRUCTION AND APPLICATION OF A FLOWCELL FOR ATTENUATED TOTAL REFLECTANCE-FOURIER-TRANSFORM INFRARED SPECTROMETER/SCANNING CONFOCAL LASER MICROSCOPE STUDIES OF ORAL MICROBIAL COMMUNITIES SOL RFP NLM 96-104/VMS DUE 042696 POC Valerie M. Syed, Contract Specialist (301) 496-6546. The National Institutes of Dental Research (NIDR) has a requirement to develop a Fourier-Transform-Infrared-Spectroscopy (FTIR) flowcell for establishment and characterization for various conditioning films on a substratum appropriate to the oral milieu (e.g., dental enamel), and to reversibly install this flowcell on a Scanning Confocal Laser Microscope (SCLM) located at the National Institute of Dental Research (NIDR), NIH, thereby creating an instrument for on-line four-dimensional study of microbial attachment to conditioning films. The successful contractor will be provided access to the Leica TCS-4D SCLM located at NIDR, to test the suitability of the flowcell for use on the microscope stage to conduct preliminary tests. Integration onto the SCLM, and support to set necessary baseline parameters for studying orally-relevant biofilms are required. It is anticipted that a two-year, cost reimbursement(level of effort) type contract will be awarded. The total project effort is estimated at 3,400 labor hours over the two year period of performance. The skills of trained and experienced analytical chemists, microbiologists, microbial ecologists, materials science engineers and access to laboratory-scale (developmental) and projection-scale prism-coating facilities as well as analytical facilities (XPS, SIMS, and Auger) will be essential for the successful completion of this project. Request for Proposals (RFP) No. NLM 96-104/VMS will be available approximately fifteen calendar days from publication of this announcement. All responsible sources may submit a proposal which will be considered by the NIDR. This acquisition is being managed for the National Institutes of Dental Research by the Office of Acquisitions Management at the National Library of Medicine. Copies of the RFP may be obtained by writing to the National Library of Medicine, Office of Acquisitions Management, 8600 Rockville Pike, Building 38A, Room B1N17, Bethesda, Maryland 20894, Attention: Valerie M. Syed, Contract Specialist. Telephone and fax requests will not be accepted. (0058)

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