National Cancer Institute, Research Contracts Branch, PCCS, 6120 Executive Blvd, EPS/Room 635, Bethesda, MD 20892-7226

A -- PHASE I STUDIES OF NEW CHEMOPREVENTIVE AGENTS SOL MAA-N01-CN-65008-70 DUE 041096 POC Erin C. Lange, Contracting Officer Representative, Susan K. Hoffman, Contracting Officer, 301-496-8603. The National Cancer Institute, Division of Cancer Prevention and Control (DCPC), Chemoprevention Branch, in its annual requirement to seek new sources, is soliciting proposals for Master Agreement Holders for the Phase I Studies of New Chemopreventive Agents. The objective of these studies is to determine the parameters and characteristics of toxicity in humans, the safely delivered dose, and the basic clinical pharmacokinetics of agents emerging from the NCI chemoprevention agent development program so that subsequent Phase III risk reduction trials can be appropriately designed. CURRENT MA HOLDERS FOR THIS PROGRAM ARE NOT REQUIRED TO SUBMIT A PROPOSAL. MAA/RFP N01-CN-65008-70 will be available electronically on or about February 26, 1996, and may be accessed through either the NIH Gopher, or the NIH Home Page by using the following electronic mail addresses and instructions: 1) to access the NIH Gopher: Point your gopher client to GOPHER.NIH.GOV PORT 70 (you should now be in the NIH Gopher). Select ''Grant & Research Information'', then select ''R&D Requests for Proposals (RFP).'' 2) NIH Home Page (via the World Wide Web): Access the NIH Home Page by using http://www.nih.gov . Once you are at the NIH Home Page, select ''Grants & Contracts'', then select R&D Requests for Proposals (RFP).'' Please note that the MAA/RFP for this procurement has been revised to include only the Statement of Work, Sample MA, special MA requirements, the Technical Evaluation Criteria, and proposal preparation instructions. All information required for the submission of a proposal will be contained in the electronic RFP package. Following proposal submission and the initial technical review process, offerors whose proposals were judged ACCEPTABLE will be awarded an MA; they will then be eligible to compete for work as Master Agreement Order (MAO) RFP's are issued. Responses to the MAA/RFP will be due on or about April 10, 1996. Point of Contact: Erin C. Lange, Contract Specialist; Electronic mail address: langee@nih.gov; Telephone: (301) 496-8603; Fax: (301) 402-8579. No collect calls will be accepted (0038)

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