DIRECTOR, USAMRAA, MCMR-AAA, BLDG 820, FORT DETRICK, FREDERICK MD 21702-5014

A -- TREATMENT FOR SKIN INJURY ASSOCIATED WITH EPIDERMOLYSIS BULLOSA (EB) SOL CBD&&&-9512-0003 POC Craig D. Lebo, (301) 619-2036 (Site Code DAMD17) The U.S. Army Medical Research and Materiel Command is currently soliciting proposals for the design and execution of studies to elucidate the mechanism and possible treatment for skin injury associated with epidermolysis bullosa (EB), a group of genetically transmitted diseases of the skin marked by the development of bullae and vesicles. Subepidermal blisters are observed in some forms of EB similar to sulfur mustard (HD)- induced vesication, and although the pathologic findings suggest some marked differences in the pathophysiology of the blisters produced, there may be some similar basement membrane components affected by HD as are deficient or absent in some forms of EB. Studies further elucidating the mechanisms of vesicle and bullae formation, as well as studies addressing novel treatment methodologies, and their relevance to other types of blister injury, are requested. Proposal guidelines are contained in the U.S. Army Medical Research and Materiel Command Broad Agency Announcement 95-1 dated October 1994 (copies available upon request). To be considered for this program proposals should be received no later than 1 March 1996. Proposals shall be forwarded: The U.S. Army Medical Research and Materiel Command, Fort Detrick, Frederick, MD 21702-5012, Telephone (301) 619-2036. (0352)

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